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SUMO1/sentrin/SMT3 Specific Peptidase 2 Proteins (SENP2)

SUMO1 (UBL1\; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. Additionally we are shipping SENP2 Antibodies (115) and SENP2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SENP2 75826 Q91ZX6
SENP2 59343 Q9HC62
SENP2 78973 Q9EQE1
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Top SENP2 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

SENP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)


Rat (Rattus)

More Proteins for SUMO1/sentrin/SMT3 Specific Peptidase 2 (SENP2) Interaction Partners

Mouse (Murine) SUMO1/sentrin/SMT3 Specific Peptidase 2 (SENP2) interaction partners

  1. SENP2 regulates Drp1 sumoylation and stability critical for mitochondrial morphogenesis.SENP2 plays role in mitochondria mediated neural degeneration.

  2. This study identified an animal model of SUDEP, which is caused by alteration of a posttranslational protein modification pathway (SUMOylation) on a unique voltage-gated potassium channel (Kv7.2/Kv7.3)

  3. These results reveal the important role of SENP2 in the regulation of myostatin (show MSTN Proteins) expression and myogenesis.

  4. SENP2 represses glycolysis and shifts glucose metabolic strategy

  5. Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity.

  6. a mechanism underlying the SENP2-mediated regulation of Mdm2 (show MDM2 Proteins) that is critical for genome integrity in p53 (show TP53 Proteins)-dependent stress responses.

  7. SENP2 de-SUMOylates PPARgamma (show PPARG Proteins) in myotubes, and de-SUMOylation of PPARgamma (show PPARG Proteins) selectively increases the expression of some PPARgamma (show PPARG Proteins) target genes.

  8. Senp2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.

  9. These results establish a critical role for SENP2 in the regulation of adipogenesis by desumoylation.

  10. SUMO-1 protease-1 regulates gene transcription through PML (show PML Proteins).

Human SUMO1/sentrin/SMT3 Specific Peptidase 2 (SENP2) interaction partners

  1. SENP2 (show SUMO1 Proteins) inhibits MMP13 (show MMP13 Proteins) expression in BC cells through de-SUMOylation of TBL1 (show TBL1X Proteins)/TBLR1 (show TBL1XR1 Proteins), which inhibits nuclear translocation of beta-catenin (show CTNNB1 Proteins).

  2. miR (show MLXIP Proteins)-181b targets SENP2 (show SUMO1 Proteins) and positively regulated NF-kappaB (show NFKB1 Proteins) activity. NF-kappaB (show NFKB1 Proteins) activation by DNA damage in GBM cells confers resistance to radiation-induced death.

  3. data identify SENP2 as an important regulator of fatty acid metabolism in skeletal muscle

  4. SENP2 (show SUMO1 Proteins) regulates the transcriptional function of MEF2A (show MEF2A Proteins) via direct de-SUMOylation.

  5. p90RSK-mediated SENP2-T368 phosphorylation is a master switch in disturbed-flow-induced signaling.

  6. we show that WWOX required for stabilization of beta-catenin regulated by SENP2 in hepatocellular carcinoma cells

  7. ESR1 repression by SENP2 is independent of its SUMO protease activity.

  8. Many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are codepleted.

  9. Chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis; SENP1 and SENP2 are important mediators of this control.

  10. The SENP1 (show SENP1 Proteins) levels are influenced by the presence of Nup153 (show NUP153 Proteins), whereas SENP2 (show SUMO1 Proteins) is not sensitive to changes in Nup153 (show NUP153 Proteins) abundance.

SENP2 Protein Profile

Protein Summary

SUMO1 (UBL1\; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.

Gene names and symbols associated with SENP2

  • SUMO/sentrin specific peptidase 2 (Senp2)
  • SUMO1/sentrin/SMT3 specific peptidase 2 (SENP2)
  • Sumo1/sentrin/SMT3 specific peptidase 2 (Senp2)
  • 2310007L05Rik protein
  • 4930538C18Rik protein
  • AI646780 protein
  • AW554757 protein
  • Axam protein
  • AXAM2 protein
  • mKIAA1331 protein
  • SMT3IP2 protein
  • SuPr-1 protein

Protein level used designations for SENP2

SUMO-1 protease 1 , SUMO-1 protease-1 , SUMO-1/Smt3-specific isopeptidase 2 , SUMO/sentrin specific protease 2 , axam2 , sentrin-specific protease 2 , sentrin/SUMO-specific protease SENP2 , SMT3-specific isopeptidase 2 , SUMO1/sentrin/SMT3 specific protease 2 , Axin-associating molecule , SUMO/sentrin specific peptidase 2

75826 Mus musculus
59343 Homo sapiens
78973 Rattus norvegicus
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