anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Antibodies

The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteins (9) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMARCB1 6598 Q12824
SMARCB1 20587 Q9Z0H3
SMARCB1 361825  
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Top anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antibodies at antibodies-online.com

Showing 10 out of 133 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SMARCB1 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control: Human Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB <b>WB Suggested Anti-SMARCB1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-SMARCB1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Jurkat cell lysate <br /> SMARCB1 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SMARCB1 Antibody (N-term) (ABIN658274) western blot analysis in mouse brain tissue lysates (35 µg/lane). This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL   Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;   Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of BAF47 on a mouse cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- BAF47 antibody. 50 μg Log in to see 6 to 8 Days
$168.74
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SNF5 Antibody [NBP1-90014] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Western Blot: SNF5 Antibody [NBP1-90014] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated WB SMARCB1 monoclonal antibody (M01), clone 3E10. Western Blot analysis of SMARCB1 expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: SMARCB1/SNF5 Antibody [ABIN252863] - Detection of Human and Mouse SMARCB1/SNF5 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded), 293T (T, 50 mcg) and mouse NIH3T3 (M, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- SMARCB1/SNF5 antibody ABIN252863 used for WB at 0.4 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. SMARCB1/SNF5 was also immunoprecipitated by another rabbit anti-SMARCB1/SNF5 antibody, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 minutes (B). Western Blot: SNF5 Antibody [ABIN2528635] - Whole cell lysate (50 ug) from HeLa, 293T, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-SMARCB1/SNF5 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated ChIP, IC, IF, IHC, IP, WB Immunofluorescent analysis of INI1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i 200 μL Log in to see 13 to 14 Days
$487.50
Details

SMARCB1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antibodies

  1. Human Monoclonal SMARCB1 Primary Antibody for IF, WB - ABIN968741 : Bruder, Dumanski, Kedra: The mouse ortholog of the human SMARCB1 gene encodes two splice forms. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal SMARCB1 Primary Antibody for IF, WB - ABIN968742 : Guidi, Sands, Zambrowicz, Turner, Demers, Webster, Smith, Imbalzano, Jones: Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. in Molecular and cellular biology 2001 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SMARCB1 Primary Antibody for ICC, IF - ABIN252863 : Young, Jacks: Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  4. Human Monoclonal SMARCB1 Primary Antibody for WB - ABIN393962 : Wu, Ho, Lin, Lin: Rhabdoid papillary meningioma: a clinicopathologic case series study. in Neuropathology : official journal of the Japanese Society of Neuropathology 2011 (PubMed)

  5. Human Polyclonal SMARCB1 Primary Antibody for IF (p), IHC (p) - ABIN762566 : McAndrew, Gjidoda, Tagore, Miksanek, Floer: Chromatin Remodeler Recruitment during Macrophage Differentiation Facilitates Transcription Factor Binding to Enhancers in Mature Cells. in The Journal of biological chemistry 2016 (PubMed)

  6. Human Polyclonal SMARCB1 Primary Antibody for WB - ABIN2778302 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal SMARCB1 Primary Antibody for IHC (p), ELISA - ABIN562912 : Scurr, Pupo, Becker, Lai, Schrama, Haferkamp, Irvine, Scolyer, Mann, Becker, Kefford, Rizos: IGFBP7 is not required for B-RAF-induced melanocyte senescence. in Cell 2010 (PubMed)

  8. Human Polyclonal SMARCB1 Primary Antibody for ICC, IF - ABIN4354923 : Singh, Archer: Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. in Nucleic acids research 2014 (PubMed)

More Antibodies against SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) interaction partners

  1. Of the 34 undifferentiated endometrial carcinomas examined, 17 (50%) exhibited SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex inactivation, with 11 tumors showing complete loss of both ARID1A (show ARID1A Antibodies) and ARID1B (show ARID1B Antibodies), 5 showing complete loss of BRG1 (show SMARCA4 Antibodies) and 1 showing complete loss of INI1. Ten of the remaining 17 undifferentiated carcinomas showed the following alterations: 5 tumors (15%) showed loss of ARID1A (show ARID1A Antibodies) only with intact ARID1B (show ARID1B Antibodies), BRG1 (show SMARCA4 Antibodies), and INI1 expression.

  2. Our study, the first comprehensive analysis of RMC, supports a pivotal role for SMARCB1 in its development.

  3. HRAS (show HRAS Antibodies) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (show PLAG1 Antibodies) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (show PLAG1 Antibodies) and HMGA2 correlates with the presence of TP53 (show TP53 Antibodies), FBXW7 (show FBXW7 Antibodies) mutations, or SMARCB1 deletion.

  4. Intronic hotspot variant of SMARCB1 was identified in atypical teratoid and rhabdoid tumors of two patients. This cryptic variant was absent in the germline DNA of both patients.

  5. These highly mobile and invasive cells no longer depend on KRAS signaling and rely on the aberrant activation of mesenchymal programs regulated by the chromatin remodeling factor (show ASH1L Antibodies) SMARCB1. Mouse models showed that Smarcb1 ablation could intensify cancer spread; conversely, restoring Smarcb1 slowed tumor growth and restored the cells to their less invasive, epithelial form

  6. BAF57 (show SMARCE1 Antibodies), BAF60a (show SMARCD1 Antibodies) and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells

  7. Low SNF5 expression is associated with Hepatocellular Carcinoma.

  8. SMARCB1 is required for widespread BAF (show BANF1 Antibodies) complex-mediated activation of enhancers and bivalent promoters.

  9. Interactions have been indicated between SMARCB1/INI1 protein and key proteins in various pathways related to tumor proliferation and progression.

  10. The common loss of INI1 expression in rhabdoid and non-rhabdoid tumors will also open new therapeutic doors by developing targeted therapy strategies which may help to consolidate an initial treatment response to conventional radiochemotherapy.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) interaction partners

  1. Data show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 (show NF2 Antibodies) gene inactivation causes shwannomas.

  2. The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.

  3. These results support recent findings regarding the effectivity of EGFR (show EGFR Antibodies) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (show EGFR Antibodies) signaling in Rhabdoid tumors is SMARCB1 dependent.

  4. these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

  5. This study show here that loss of Smarcb1 and Smarca4 (show SMARCA4 Antibodies) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.

  6. results show that Smarcb1 is required for transcriptional activation of Igfbp7 (show IGFBP7 Antibodies) and show that re-introduction of Igfbp7 (show IGFBP7 Antibodies) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis

  7. We find that inactivation of either Brg1 (show SMARCA4 Antibodies) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.

  8. SNF5 is a key mediator of Hedgehog (show SHH Antibodies) signaling and that aberrant activation of GLI1 (show GLI1 Antibodies) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.

  9. Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (show CBX2 Antibodies) gene EZH2 (show EZH2 Antibodies).

  10. SNF5 knockdown inhibits p53 (show TP53 Antibodies) translation by eIF4E (show EIF4E Antibodies) and replacement of eIF4E (show EIF4E Antibodies) in SNF5 knockdown cells restores p53 (show TP53 Antibodies) expression and cell survival

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Antigen Profile

Protein Summary

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMARCB1

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (Smarcb1) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog (smarcb1.S) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b (smarcb1b) antibody
  • AU020204 antibody
  • Baf47 antibody
  • fc51b01 antibody
  • hSNFS antibody
  • Ini1 antibody
  • MRD15 antibody
  • RDT antibody
  • RTPS1 antibody
  • Sfh1p antibody
  • smarcb1 antibody
  • Snf5 antibody
  • SNF5/INI1 antibody
  • SNF5L1 antibody
  • Snr1 antibody
  • wu:fc51b01 antibody

Protein level used designations for SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 , matrix metalloproteinase 11 (stromelysin 3) , BAF47 , BRG1-associated factor 47 , SNF5 homolog , hSNF5 , integrase interactor 1 protein , malignant rhabdoid tumor suppressor , sucrose nonfermenting, yeast, homolog-like 1 , mSNF5 , SWI/SNF-related matrix associated protein

GENE ID SPECIES
769489 Gallus gallus
537412 Bos taurus
6598 Homo sapiens
20587 Mus musculus
443934 Xenopus laevis
486407 Canis lupus familiaris
361825 Rattus norvegicus
30731 Danio rerio
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