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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 Proteins (SMARCA2)

The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Additionally we are shipping SMARCA2 Antibodies (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMARCA2 6595 P51531
SMARCA2 67155 Q6DIC0
Rat SMARCA2 SMARCA2 361745  
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Top SMARCA2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag Recombinant SMARCA2 / BRM (1367-1511), GST-tag activity using AlphaLISA. SMARCA2 / BRM (1367-1511), GST-tag was used in an AlphaLISA assay to determine enzyme linearity. This data was generated and kindly provided courtesy of ChemPartner. Recombinant SMARCA2 / BRM (1367-1511), GST-tag protein gel. SMARCA2 / BRM (1367-1511), GST-tag protein was run on an SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details

SMARCA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. our data suggest that concomitant loss of SMARCA2 and SMARCA4 (show SMARCA4 Proteins) is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.

  2. this study shows for the first time novel SMARCA4 (show SMARCA4 Proteins)-deficient and SMARCA2-deficient variants in undifferentiated gastrointestinal tract carcinomas

  3. SMARCA4 loss, either alone or with SMARCA2, is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type, restoration of either SWI/SNF ATPase can inhibit the growth of SCCOHT cell lines

  4. We report, for the first time, co-inactivation and frequent mutations of SMARCB1 (show SMARCB1 Proteins), SMARCA2 and PBRM1 (show PBRM1 Proteins) in MRTs.

  5. The miR (show MLXIP Proteins)-199a/Brm/EGR1 (show EGR1 Proteins) axis is a determinant of anchorage-independent growth in epithelial tumor cell lines

  6. Knockout of BRG1 (show SMARCA4 Proteins) or BRM using CRISPR/Cas9 technology resulted in the loss of viability, consistent with a requirement for both enzymes in triple negative breast cancer cells

  7. BAF (show BANF1 Proteins) complex gene SMARCA2 is mutated in Coffin-Siris syndrome patients.

  8. Phenotype and genotype in Nicolaides-Baraitser syndrome patients with SMARCA2 mutations

  9. Over-expression of BRM in melanoma cells that harbor oncogenic BRAF (show BRAF Proteins) promoted changes in cell cycle progression and apoptosis consistent with a tumor suppressive role.

  10. Findings suggest that the BRM promoter double insertion homozygotes may be associated with an increased risk of early-stage UADT cancers independent of smoking status and histology.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.

  2. Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (show SMARCC2 Proteins) at different stages promotes reprogramming.

  3. Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes.

  4. Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes

  5. Data suggest that Brg1 (show SMARCA4 Proteins) and Brm integrate various proinflammatory cues into cell adhesion molecule (show MCAM Proteins) transactivation in endothelial injury.

  6. A SMARCA2-containing residual SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex underlies the oncogenic activity of SMARCA4 (show SMARCA4 Proteins) mutant cancers.

  7. study identifies NO and HDAC2 (show HDAC2 Proteins) nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons

  8. The absence of Brm increased skin and ocular photocarcinogenesis in mice.

  9. Brm functionally compensates for Brg1 (show SMARCA4 Proteins) in vivo and that there are significant changes in the relative importance of BRG1 (show SMARCA4 Proteins)- and BRM-catalyzed SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes during the development of an essential cell lineage.

  10. demonstrate a strong functional association between these polymorphisms and loss of BRM expression. These polymorphisms thus have the potential to identify a sub-population of smokers at greater lung cancer risk

SMARCA2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Gene names and symbols associated with SMARCA2

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (smarca2)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (Smarca2)
  • 2610209L14Rik protein
  • BAF190 protein
  • Brahma protein
  • brm protein
  • hBRM protein
  • hSNF2a protein
  • NCBRS protein
  • psa-4 protein
  • SNF2 protein
  • SNF2alpha protein
  • Snf2l2 protein
  • SNF2LA protein
  • Sth1p protein
  • SWI2 protein
  • wu:fa56c07 protein
  • wu:fi27f11 protein
  • zgc:66238 protein

Protein level used designations for SMARCA2

ATP-dependent helicase SMARCA2 , BAF190B , BRG1-associated factor 190B , SNF2-alpha , SNF2/SWI2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 , global transcription activator homologous sequence , probable global transcription activator SNF2L2 , protein brahma homolog , sucrose nonfermenting 2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 , subunit of the SWI/SNF chromatin remodeling complex , phasmid Socket Absent PSA-4

GENE ID SPECIES
6595 Homo sapiens
403380 Xenopus laevis
396040 Gallus gallus
67155 Mus musculus
334032 Danio rerio
476335 Canis lupus familiaris
540904 Bos taurus
361745 Rattus norvegicus
100126853 Sus scrofa
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