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The protein encoded by SMARCA4 is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (6) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Kits (1) and many more products for this protein.
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Human Monoclonal SMARCA4 Primary Antibody for IHC (p), WB - ABIN614772
Ooi, Belyaev, Miyake, Wood, Buckley: BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. in The Journal of biological chemistry 2006
Show all 4 references for ABIN614772
Human Monoclonal SMARCA4 Primary Antibody for WB - ABIN343708
Griffin, Brennan, Magnuson: The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. in Development (Cambridge, England) 2008
Show all 4 references for ABIN343708
Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN871762
Park, Venteicher, Hong, Choi, Jun, Shkreli, Chang, Meng, Cheung, Ji, McLaughlin, Veenstra, Nusse, McCrea, Artandi: Telomerase modulates Wnt signalling by association with target gene chromatin. in Nature 2009
Show all 3 references for ABIN871762
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668499
Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668498
de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006
BRG1 is involved in the progression and metastasis of breast cancer and can serve as a novel biomarker predictive of distant metastasis and patient outcomes.
Results provide evidence that BRG1 and SMARCAL1 (show SMARCAL1 Antibodies) regulate each other. BRG1 binds to the SMARCAL1 (show SMARCAL1 Antibodies) promoter, while SMARCAL1 (show SMARCAL1 Antibodies) binds to the brg1 promoter. During DNA damage, the occupancy of SMARCAL1 (show SMARCAL1 Antibodies) on the brg1 promoter increases coinciding with an increase in BRG1 occupancy on the SMARCAL1 (show SMARCAL1 Antibodies) promoter, leading to increased brg1 and SMARCAL1 (show SMARCAL1 Antibodies) transcripts respectively.
The CRISPR/Cas9 system may control a pro-oncogenic splicing process through the exclusion of EDA (show EDA Antibodies) exon from the FN gene, leading to inhibition of motility, invasion and proliferation of cancer cells.
Knock down of BRG1 in resistant cells restored sensitivity to retinoic acid-mediated differentiation, from early gene expression to terminal functional capacity.
Data indicate that SMARCA4 protein inactivation is the main cause of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
our data suggest that concomitant loss of SMARCA2 (show SMARCA2 Antibodies) and SMARCA4 is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.
Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1.
These results suggest that ARPE-19 cells possess an AHR (show AHR Antibodies)-mediated transcription pathway with different target gene specificity, and that BRG1 is required for AHR (show AHR Antibodies)-mediated transcription in ARPE-19 cells.
this study shows for the first time novel SMARCA4-deficient and SMARCA2 (show SMARCA2 Antibodies)-deficient variants in undifferentiated gastrointestinal tract carcinomas
Brg-1 inhibits the transcriptional activity of miR (show MLXIP Antibodies)-550a-5p promoter, and decreased Brg-1 expression increased miR (show MLXIP Antibodies)-550a-5p expression.
SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin remodeler subunits Brg1 and Brm (show SMARCA2 Antibodies) are expressed differentially during drug-induced liver injury and regeneration in a mouse model.
these findings described a role for BRG1 and BRM (show SMARCA2 Antibodies) in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte
show that epigenetic chromatin remodeling (via a Brg1 and p53 (show TP53 Antibodies)/p21 (show D4S234E Antibodies)-dependent process) determines the aNSCs and progenitor maintenance and responsiveness of neurogenesis.
The stress-induced Brg1-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
MITF (show MITF Antibodies) interacts with BRG1 to promote GATA4 (show GATA4 Antibodies) expression in cardiac hypertrophy.
SMARCA4 is involved in the TOP1 (show TOP1 Antibodies) recruitment to general chromatin, which suppresses transcription-associated genomic instability.
the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
Brg1 may play a critical role in neuronal growth by regulating the NR2B (show GRIN2B Antibodies)-NR2A (show GRIN2A Antibodies) switch in the postnatal cortex
Brg1 has a role in coordinating multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
The data suggest that BRG1 governs Nanog expression via a dual mechanism involving histone deacetylation and nucleosome remodeling.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4