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The protein encoded by SMARCA4 is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (6) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Kits (1) and many more products for this protein.
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Human Monoclonal SMARCA4 Primary Antibody for IHC (p), WB - ABIN614772
Ooi, Belyaev, Miyake, Wood, Buckley: BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. in The Journal of biological chemistry 2006
Show all 4 references for ABIN614772
Human Monoclonal SMARCA4 Primary Antibody for WB - ABIN343708
Griffin, Brennan, Magnuson: The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. in Development (Cambridge, England) 2008
Show all 4 references for ABIN343708
Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN871762
Park, Venteicher, Hong, Choi, Jun, Shkreli, Chang, Meng, Cheung, Ji, McLaughlin, Veenstra, Nusse, McCrea, Artandi: Telomerase modulates Wnt signalling by association with target gene chromatin. in Nature 2009
Show all 3 references for ABIN871762
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668498
de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668499
Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009
Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1.
These results suggest that ARPE-19 cells possess an AHR (show AHR Antibodies)-mediated transcription pathway with different target gene specificity, and that BRG1 is required for AHR (show AHR Antibodies)-mediated transcription in ARPE-19 cells.
this study shows for the first time novel SMARCA4-deficient and SMARCA2 (show SMARCA2 Antibodies)-deficient variants in undifferentiated gastrointestinal tract carcinomas
Brg-1 inhibits the transcriptional activity of miR (show MLXIP Antibodies)-550a-5p promoter, and decreased Brg-1 expression increased miR (show MLXIP Antibodies)-550a-5p expression.
these data uncover a direct regulatory relationship between miR (show MLXIP Antibodies)-302 and the Brg1 chromatin remodeling complex that controls gene expression and cell fate decisions in hESCs and suggests that similar mechanisms are at play during early human development
The results do not support our hypothesis that common germline genetic variants in the SMARCA4 genes is associated with the risk of developing medulloblastoma.
Loss of SMARCA4 expression is sensitive/specific for the diagnosis of small cell carcinoma of ovary, hypercalcemic type.
SMARCA4 is involved in the TOP1 (show TOP1 Antibodies) recruitment to general chromatin, which suppresses transcription-associated genomic instability.
the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
SMARCA4 loss, either alone or with SMARCA2 (show SMARCA2 Antibodies), is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type, restoration of either SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) ATPase (show DNAH8 Antibodies) can inhibit the growth of SCCOHT cell lines
The stress-induced Brg1-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
MITF (show MITF Antibodies) interacts with BRG1 to promote GATA4 (show GATA4 Antibodies) expression in cardiac hypertrophy.
Brg1 may play a critical role in neuronal growth by regulating the NR2B (show GRIN2B Antibodies)-NR2A (show GRIN2A Antibodies) switch in the postnatal cortex
Brg1 has a role in coordinating multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
The data suggest that BRG1 governs Nanog expression via a dual mechanism involving histone deacetylation and nucleosome remodeling.
SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling
Endocardial Brg1-deficient mouse embryos develop thickened and disorganized semilunar valve cusps
MITF (show MITF Antibodies)-BRG1 interplay thus plays an essential role in transcription regulation in melanoma.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4