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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (SMARCA4)

The protein encoded by SMARCA4 is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Antibodies (88) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMARCA4 6597 P51532
Rat SMARCA4 SMARCA4 171379  
SMARCA4 20586 Q3TKT4
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Top SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant SMARCA4 / BRG1 (1448-1569) protein gel. SMARCA4 / BRG1 (1448-1569) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

SMARCA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. our data suggest that concomitant loss of SMARCA2 (show SMARCA2 Proteins) and SMARCA4 is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.

  2. Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1.

  3. These results suggest that ARPE-19 cells possess an AHR (show AHR Proteins)-mediated transcription pathway with different target gene specificity, and that BRG1 is required for AHR (show AHR Proteins)-mediated transcription in ARPE-19 cells.

  4. this study shows for the first time novel SMARCA4-deficient and SMARCA2 (show SMARCA2 Proteins)-deficient variants in undifferentiated gastrointestinal tract carcinomas

  5. Brg-1 inhibits the transcriptional activity of miR (show MLXIP Proteins)-550a-5p promoter, and decreased Brg-1 expression increased miR (show MLXIP Proteins)-550a-5p expression.

  6. these data uncover a direct regulatory relationship between miR (show MLXIP Proteins)-302 and the Brg1 chromatin remodeling complex that controls gene expression and cell fate decisions in hESCs and suggests that similar mechanisms are at play during early human development

  7. The results do not support our hypothesis that common germline genetic variants in the SMARCA4 genes is associated with the risk of developing medulloblastoma.

  8. Loss of SMARCA4 expression is sensitive/specific for the diagnosis of small cell carcinoma of ovary, hypercalcemic type.

  9. SMARCA4 is involved in the TOP1 (show TOP1 Proteins) recruitment to general chromatin, which suppresses transcription-associated genomic instability.

  10. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. The stress-induced Brg1-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  2. MITF (show MITF Proteins) interacts with BRG1 to promote GATA4 (show GATA4 Proteins) expression in cardiac hypertrophy.

  3. SMARCA4 is involved in the TOP1 (show TOP1 Proteins) recruitment to general chromatin, which suppresses transcription-associated genomic instability.

  4. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.

  5. Brg1 may play a critical role in neuronal growth by regulating the NR2B (show GRIN2B Proteins)-NR2A (show GRIN2A Proteins) switch in the postnatal cortex

  6. Brg1 has a role in coordinating multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma

  7. The data suggest that BRG1 governs Nanog expression via a dual mechanism involving histone deacetylation and nucleosome remodeling.

  8. SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling

  9. Endocardial Brg1-deficient mouse embryos develop thickened and disorganized semilunar valve cusps

  10. MITF (show MITF Proteins)-BRG1 interplay thus plays an essential role in transcription regulation in melanoma.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMARCA4

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4)
  • b2b692Clo protein
  • BAF190 protein
  • BAF190A protein
  • brg-1 protein
  • Brg1 protein
  • HP1-BP72 protein
  • hSNF2b protein
  • MRD16 protein
  • RTPS2 protein
  • SMARCA4 protein
  • SNF2 protein
  • SNF2beta protein
  • SNF2L4 protein
  • SNF2LB protein
  • SW1/SNF protein
  • SWI2 protein

Protein level used designations for SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 , transcription activator BRG1-like , ATP-dependent helicase SMARCA4 , BRG1-associated factor 190A , BRM/SWI2-related gene 1 , SNF2-beta , SNF2-like 4 , brahma protein-like 1 , global transcription activator homologous sequence , homeotic gene regulator , mitotic growth and transcription activator , nuclear protein GRB1 , protein BRG-1 , protein brahma homolog 1 , sucrose nonfermenting-like 4 , transcription activator BRG1 , BAF190A , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 , SWI/SNF related transcriptional activator , WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

GENE ID SPECIES
455720 Pan troglodytes
476710 Canis lupus familiaris
100415454 Callithrix jacchus
100446301 Pongo abelii
100464834 Ailuropoda melanoleuca
6597 Homo sapiens
171379 Rattus norvegicus
20586 Mus musculus
414274 Bos taurus
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