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anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antibodies

The protein encoded by SMARCAL1 is a member of the SWI/SNF family of proteins. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Proteins (4) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMARCAL1 54380 Q8BJL0
SMARCAL1 316477 B4F769
SMARCAL1 50485 Q9NZC9
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Top anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SMARCAL1 Antibody Titration: 1.25ug/mlPositive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SMARCAL1 antibody ABIN214381 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot using Affinity Purified anti-SmarcAL1 antibody shows detection of a band ~106 kDa band (arrowhead) corresponding to SmarcAL1 in human derived cultured cell lysates (HeLa nuclear extract lane 1, HeLa lane 2, A431 lane 3, Jurkat lane 4, and 293 lane 5). Approximately 5µg of each lysates was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-SmarcAL1 antibody. Signal was detected using standard techniques. SmarcAL1 is the band seen between the 97 and 116kD markers. 100 μg Log in to see 2 to 3 Days
$369.00
Details
Cow Mouse Un-conjugated IP, WB   100 μg Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

SMARCAL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)
,
,
Rat (Rattus)


Human
,
,

Top referenced anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies

  1. Human Polyclonal SMARCAL1 Primary Antibody for EIA, WB - ABIN401264 : Coleman, Eisen, Mohrenweiser: Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse. in Genomics 2000 (PubMed)
    Show all 3 references for ABIN401264

  2. Cow (Bovine) Monoclonal SMARCAL1 Primary Antibody for IP, WB - ABIN2668353 : Mesner, Sutherland, Hockensmith: DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases. in Biochemistry 1992 (PubMed)
    Show all 2 references for ABIN2668353

  3. Cow (Bovine) Polyclonal SMARCAL1 Primary Antibody for WB - ABIN2775720 : Clewing, Fryssira, Goodman, Smithson, Sloan, Lou, Huang, Choi, Lücke, Alpay, André, Asakura, Biebuyck-Gouge, Bogdanovic, Bonneau, Cancrini, Cochat, Cockfield, Collard, Cordeiro, Cormier-Daire, Cransberg, Cutka, Deschenes, Ehrich, Fründ, Georgaki, Guillen-: Schimke immunoosseous dysplasia: suggestions of genetic diversity. in Human mutation 2007 (PubMed)

  4. Human Polyclonal SMARCAL1 Primary Antibody for IHC (p), ELISA - ABIN214381 : Patel, Rowe, Winters, Ohls: Elevated erythropoietin mRNA and protein concentrations in the developing human eye. in Pediatric research 2008 (PubMed)

More Antibodies against SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Interaction Partners

Zebrafish SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. found that SMARCAL1 was transcriptionally inhibited by E2F6 (show E2F6 Antibodies), an important cell cycle regulator (show CDKN2A Antibodies). Over-expression of E2F6 (show E2F6 Antibodies) in zebrafish embryos reduced the expression of smarcal1 mRNA and induced developmental defects similar to those in smarcal1 morphants

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  2. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

  3. Mutation of predicted DNA-binding residues in the HARP (show C5orf13 Antibodies) domain dramatically reduced fork binding and regression activities of SMARCAL1 catalytic domain.

  4. did not find evidence of defective NER (show NR1H2 Antibodies) or NHEJ; however, Smarcal1-deficient mice were hypersensitive to several genotoxic agents

  5. SMARCAL1 annealing helicase (show DNA2 Antibodies) buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD.

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. SMARCAL1 negatively regulates c-myc (show MYC Antibodies) transcription by altering the conformation of its promoter region during differentiation.

  2. Mutations in human SMARCAL1 that result in loss in ATPase (show DNAH8 Antibodies) activity lead to increased replication stress and therefore possibly manifestation of Schimke immuno-osseous dysplasia.

  3. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  4. The results suggest that Smarcal1 enhances nonhomologous end-joining repair, presumably by interacting with RPA at unwound single-strand sequences and then facilitating annealing at double-strand-break ends.

  5. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

  6. In addition to its annealing helicase activity, which eliminates the natural binding substrate for RPA, HARP blocks the phosphorylation of RPA by DNA-PK.

  7. We present here the first evidence of intrinsic chromosomal instability in a severe SMARCAL1-deficient patient with a clinical picture of SIOD.

  8. Conserved motifs are required for RPA32 (show RPA2 Antibodies) binding the the N-terminus of SMARCAL1.

  9. report provided the clinical and genetic description of a mild phenotype of Schimke immuno-osseous dysplasia associated with nephrotic proteinuria, decreasing after combined therapy with ACE (show ACE Antibodies) inhibitors and sartans.

  10. study reports the characterization of the RPA32C-SMARCAL1 interface at the molecular level; implications of results are discussed with respect to the recruitment of SMARCAL1 and other DNA damage response and repair proteins to stalled replication forks

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Gene names and symbols associated with SMARCAL1

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (smarcal1) antibody
  • SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1) antibody
  • Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1) antibody
  • 6030401P21Rik antibody
  • AI851716 antibody
  • HARP antibody
  • HHARP antibody
  • im:7145331 antibody
  • Mharp antibody
  • si:ch211-239d11.1 antibody
  • SMARCAL1 antibody

Protein level used designations for SMARCAL1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 , hepA-related protein , sucrose nonfermenting protein 2-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1-like , ATP-driven annealing helicase , HepA-related protein , SMARCA-like protein 1 , Sucrose nonfermenting protein 2-like 1

GENE ID SPECIES
396031 Gallus gallus
459930 Pan troglodytes
560412 Danio rerio
695741 Macaca mulatta
780385 Xenopus (Silurana) tropicalis
100013505 Monodelphis domestica
100050615 Equus caballus
100348145 Oryctolagus cuniculus
100411539 Callithrix jacchus
100454019 Pongo abelii
100471163 Ailuropoda melanoleuca
100606153 Nomascus leucogenys
100620418 Sus scrofa
54380 Mus musculus
316477 Rattus norvegicus
50485 Homo sapiens
478903 Canis lupus familiaris
338072 Bos taurus
734728 Xenopus laevis
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