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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Proteins (SMARCAL1)

The protein encoded by SMARCAL1 is a member of the SWI/SNF family of proteins. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies (32) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMARCAL1 54380 Q8BJL0
Rat SMARCAL1 SMARCAL1 316477 B4F769
SMARCAL1 50485 Q9NZC9
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Top SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SMARCAL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Interaction Partners

Zebrafish SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. found that SMARCAL1 was transcriptionally inhibited by E2F6 (show E2F6 Proteins), an important cell cycle regulator. Over-expression of E2F6 (show E2F6 Proteins) in zebrafish embryos reduced the expression of smarcal1 mRNA and induced developmental defects similar to those in smarcal1 morphants

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  2. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

  3. Mutation of predicted DNA-binding residues in the HARP (show C5orf13 Proteins) domain dramatically reduced fork binding and regression activities of SMARCAL1 catalytic domain.

  4. did not find evidence of defective NER (show NR1H2 Proteins) or NHEJ; however, Smarcal1-deficient mice were hypersensitive to several genotoxic agents

  5. SMARCAL1 annealing helicase buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD.

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. SMARCAL1 negatively regulates c-myc (show MYC Proteins) transcription by altering the conformation of its promoter region during differentiation.

  2. Mutations in human SMARCAL1 that result in loss in ATPase activity lead to increased replication stress and therefore possibly manifestation of Schimke immuno-osseous dysplasia.

  3. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  4. The results suggest that Smarcal1 enhances nonhomologous end-joining repair, presumably by interacting with RPA at unwound single-strand sequences and then facilitating annealing at double-strand-break ends.

  5. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

  6. In addition to its annealing helicase activity, which eliminates the natural binding substrate for RPA, HARP blocks the phosphorylation of RPA by DNA-PK.

  7. We present here the first evidence of intrinsic chromosomal instability in a severe SMARCAL1-deficient patient with a clinical picture of SIOD.

  8. Conserved motifs are required for RPA32 (show RPA2 Proteins) binding the the N-terminus of SMARCAL1.

  9. report provided the clinical and genetic description of a mild phenotype of Schimke immuno-osseous dysplasia associated with nephrotic proteinuria, decreasing after combined therapy with ACE (show ACE Proteins) inhibitors and sartans.

  10. study reports the characterization of the RPA32C-SMARCAL1 interface at the molecular level; implications of results are discussed with respect to the recruitment of SMARCAL1 and other DNA damage response and repair proteins to stalled replication forks

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Gene names and symbols associated with SMARCAL1

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (smarcal1)
  • SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1)
  • Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1)
  • 6030401P21Rik protein
  • AI851716 protein
  • HARP protein
  • HHARP protein
  • im:7145331 protein
  • Mharp protein
  • si:ch211-239d11.1 protein
  • SMARCAL1 protein

Protein level used designations for SMARCAL1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 , hepA-related protein , sucrose nonfermenting protein 2-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1-like , ATP-driven annealing helicase , HepA-related protein , SMARCA-like protein 1 , Sucrose nonfermenting protein 2-like 1

GENE ID SPECIES
396031 Gallus gallus
459930 Pan troglodytes
560412 Danio rerio
695741 Macaca mulatta
780385 Xenopus (Silurana) tropicalis
100013505 Monodelphis domestica
100050615 Equus caballus
100348145 Oryctolagus cuniculus
100411539 Callithrix jacchus
100454019 Pongo abelii
100471163 Ailuropoda melanoleuca
100606153 Nomascus leucogenys
100620418 Sus scrofa
54380 Mus musculus
316477 Rattus norvegicus
50485 Homo sapiens
478903 Canis lupus familiaris
338072 Bos taurus
734728 Xenopus laevis
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