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The protein encoded by SMARCD3 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 Proteins (5) and many more products for this protein.
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Human Monoclonal SMARCD3 Primary Antibody for IF, ELISA - ABIN562916
Flajollet, Lefebvre, Cudejko, Staels, Lefebvre: The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. in Molecular and cellular endocrinology 2007
Show all 3 references for ABIN562916
Cow (Bovine) Polyclonal SMARCD3 Primary Antibody for WB - ABIN2776387
Debril, Gelman, Fayard, Annicotte, Rocchi, Auwerx: Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. in The Journal of biological chemistry 2004
Human Monoclonal SMARCD3 Primary Antibody for WB - ABIN394383
Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. in Cancer research 2014
Data show that the combination of GATA binding protein 4 (Gata4 (show GATA4 Antibodies)), T-box transcription factor 5 (Tbx5 (show TBX5 Antibodies)) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.
Inhibition of Wnt5a (show WNT5A Antibodies) by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT (show WNT2 Antibodies) signaling pathways.
Deptor (show DEPTOR Antibodies) is induced by the Baf60c-Six4 (show SIX4 Antibodies) transcriptional complex and mediates activation of Akt (show AKT1 Antibodies) and glycolytic metabolism by Baf60c in a cell-autonomous manner
BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin (show INS Antibodies).
Data show a combination of only five genes (-BCL6 (show BCL6 Antibodies), T (BRACHYURY (show TBX1 Antibodies)), c-MYC (show MYC Antibodies), MITF (show MITF Antibodies) and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes.
BAF6 (show MYOD1 Antibodies)0c phosphory (show SMARCA1 Antibodies)lati (show SNRPA Antibodies)on on a conserved threonine is the signal that promotes inc (show MYOD1 Antibodies)orporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes.
GTNB (show DTNB Antibodies) directs cardiogenesis from human embryonic stem cells and induces correct cardiac development.
BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex is recruited to nuclear receptors and other transcription factors
Tat (show TAT Antibodies)-mediated activation of the HIV promoter requires the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex in synergy with the coactivator p300 (show EP300 Antibodies).
Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage
postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 (show HDAC5 Antibodies) protein and preventing the BAF60C-SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex myogenic commitment
regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus (show CER1 Antibodies) and the Baf60c/Smarcd3 subunit of the Brg1 (show SMARCA4 Antibodies)/Brm (show SMARCA2 Antibodies)-associated factors (BAF (show BANF1 Antibodies)) chromatin-remodelling complex
Overexpression of transcription factors MYOCD (show MYOCD Antibodies) and SRF alone or in conjunction with Mesp1 (show MESP1 Antibodies) and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4 (show GATA4 Antibodies), TBX5 (show TBX5 Antibodies), and MEF2C (show MEF2C Antibodies).
MyoD (show MYOD1 Antibodies) and the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) subunit BAF60c interact on the regulatory elements of MyoD (show MYOD1 Antibodies)-target genes in myoblasts, prior to activation of transcription.
Smarcd3, encoding Baf60c, a subunit of the BAF (show BANF1 Antibodies) complexes, is expressed specifically in the heart and somites in the early mouse embryo
propose a critical role for Baf60c in Notch (show NOTCH1 Antibodies)-dependent transcription and left-right asymmetry
Two highly related subunits of the core SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for retinoic acid receptors.
Smarcd3 regulates the timing of zebrafish myogenesis onset [Smarcd3]
Overexpression of smarcd3b and gata5 in zebrafish results in an enlarged heart, whereas combinatorial loss of cBAF components inhibits cardiac differentiation, demonstrating that Smarcd3b and Gata5 can induce a primitive, progenitor cell-like state.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3-like
, 60 kDa BRG-1/Brm-associated factor subunit C
, BRG1-associated factor 60C
, SWI/SNF complex 60 kDa subunit C
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
, Swp73-like protein
, chromatin remodeling complex BAF60C subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60C