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The protein encoded by SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. Additionally we are shipping SMARCE1 Proteins (5) and many more products for this protein.
Showing 10 out of 87 products:
Human Polyclonal SMARCE1 Primary Antibody for IHC, IHC (p) - ABIN251031
Link, Balasubramaniam, Sharma, Comstock, Godoy-Tundidor, Powers, Cao, Haelens, Claessens, Revelo, Knudsen: Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. in Cancer research 2008
Show all 4 references for ABIN251031
Human Polyclonal SMARCE1 Primary Antibody for ICC, IF - ABIN4282875
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Show all 2 references for ABIN4282875
Human Polyclonal SMARCE1 Primary Antibody for IHC (p), IHC - ABIN249995
Wang, Chi, Xue, Zhou, Kuo, Crabtree: Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. in Proceedings of the National Academy of Sciences of the United States of America 1998
Human Polyclonal SMARCE1 Primary Antibody for IHC (p), WB - ABIN658277
Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. in Cancer research 2014
Chicken Polyclonal SMARCE1 Primary Antibody for IHC, WB - ABIN2780465
Chen, Archer: Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. in Molecular and cellular biology 2005
Chicken Polyclonal SMARCE1 Primary Antibody for WB - ABIN2777857
Pan, Niu, Feng, Ng, Ren, Chen: Cellular transcription modulator SMARCE1 binds to HBV core promoter containing naturally occurring deletions and represses viral replication. in Biochimica et biophysica acta 2007
a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation.
Addition of the EGFR (show EGFR Antibodies) inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK (show ALK Antibodies) inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR (show EGFR Antibodies) oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors.
The results suggested that BAF57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that BAF57 may be a target for ovarian cancer therapy.
BAF (show BANF1 Antibodies) complex gene SMARCE1 is mutated in Coffin-Siris syndrome patients.
Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SmarCE1 gene.
Since both TTF1 (show NKX2-1 Antibodies) and SMARCE1 are involved in chromatin remodeling, our results imply an epigenetic regulatory mechanism for T-cell recruitment that invites deciphering.
these results demonstrate that loss of SMARCE1 is relevant to cranial as well as spinal meningiomas
Data indicate that BAF57 deregulation predisposes to metastasis.
Our findings identify multiple-spinal-meningioma disease as a new discrete entity and establish a key role for the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex in the pathogenesis of both meningiomas and tumors with clear-cell histology.
mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and/or development of breast cancer.
The N terminus of Brdt (show BRDT Antibodies) is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.
suggest a novel mechanism for transcriptional repression by TSHZ3 (show ZNF537 Antibodies) in which TSHZ3 (show ZNF537 Antibodies) and BAF57 cooperate to modulate MyoD (show MYOD1 Antibodies) activity on the Myog (show MYOG Antibodies) promoter to regulate skeletal muscle differentiation.
Data show that neuregulin-1 (show NRG1 Antibodies) (NRG) inhibition is followed by a decrease in NSC proliferation and of neuronal or oligodendroglial differentiation, and that Nrg-1 (show NRG1 Antibodies) physically interacts with BRM (show SMARCA2 Antibodies) and BAF57.
Reciprocal regulation of CD4 (show CD4 Antibodies)/CD8 (show CD8A Antibodies) expression by SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies)-like BAF (show BANF1 Antibodies) complexes.
The ER interacts with BAF57, which is stimulated by estrogen and requires both a functional hormone-binding domain & the DNA-binding region of the ER. The p160 (show MSH6 Antibodies) family of coactivators interacts with BAF57. Their potentiation of transcription depends on it.
Smarce1 (Baf27)is a critical modulator of the androgen neceptor (AR) that is capable of altering AR activity, coactivator function, and AR-dependent proliferation.
BAF (show BANF1 Antibodies) complex uses BAF57 to remodel the endogenous, H1-containing chromatin at the CD4 (show CD4 Antibodies) silencer, which facilitates the binding of Runx1 (show RUNX1 Antibodies), a key repressor of CD4 (show CD4 Antibodies) transcription.
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
, BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
, chromatin remodeling complex BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1