SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 Proteins (SMARCA2)

The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Additionally we are shipping SMARCA2 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMARCA2 6595 P51531
SMARCA2 67155 Q6DIC0
Rat SMARCA2 SMARCA2 361745  
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Top SMARCA2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 2 to 3 Days
$595.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant SMARCA2 / BRM (1367-1511) activity using AlphaScreen. SMARCA2 / BRM (1367-1511) titration and inhibition were assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. An IC50 dose response assessment of reference compound PFI-3 is also shown. This data was generated and kindly provided courtesy of ChemPartner. Recombinant SMARCA2 / BRM (1367-1511) protein gel. SMARCA2 / BRM (1367-1511) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$466.67
Details

SMARCA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. This de novo SMARCA2 missense mutation c.3721C>G, p.Gln1241Glu is the only reported mutation on exon 26 outside the ATPase domain of SMARCA2 to be associated with Nicolaides-Baraitser syndrome and adds to chromatin remodeling as a pathway for epileptogenesis.

  2. We conclude that their features better resemble Coffin-Siris syndrome, rather than Nicolaides-Baraitser syndrome and that these features likely arise from SMARCA2 over-dosage. Pure 9p duplications (not caused by unbalanced translocations) are rare. Copy number analysis in patients with features that overlap with Coffin-Siris syndrome is recommended to further determine their genetic aspects.

  3. BRM could activate JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) pathway to promote pancreatic cancer growth and chemoresistance.

  4. BRM gene mutation, chromosome 9 monosomy or BRM deletion and CpG methylation contribute collectively to the loss of BRM expression in poorly differentiated clear cell renal cell carcinoma (show MOK Proteins)

  5. BRM-741 and BRM-1321 insertion polymorphisms are associated with susceptibility to cancer.

  6. BRG1 (show SMARCA4 Proteins)/BRM and c-MYC (show MYC Proteins) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Proteins) in cancer.

  7. Two functional promoter BRM polymorphisms were not associated with pancreatic adenocarcinoma risk, but are strongly associated with survival.

  8. SMARCA4 (show SMARCA4 Proteins) and SMARCA2 deficiency is observed in 5.1% and 4.8% of non-small cell lung cancer

  9. our data suggest that concomitant loss of SMARCA2 and SMARCA4 (show SMARCA4 Proteins) is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.

  10. this study shows for the first time novel SMARCA4 (show SMARCA4 Proteins)-deficient and SMARCA2-deficient variants in undifferentiated gastrointestinal tract carcinomas

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. BRG1 (show SMARCA4 Proteins)/BRM and c-MYC (show MYC Proteins) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Proteins) in cancer.

  2. SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin remodeler subunits Brg1 (show SMARCA4 Proteins) and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.

  3. these findings described a role for BRG1 (show SMARCA4 Proteins) and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte

  4. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.

  5. Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (show SMARCC2 Proteins) at different stages promotes reprogramming.

  6. Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes.

  7. Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes

  8. Data suggest that Brg1 (show SMARCA4 Proteins) and Brm integrate various proinflammatory cues into cell adhesion molecule (show MCAM Proteins) transactivation in endothelial injury.

  9. A SMARCA2-containing residual SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex underlies the oncogenic activity of SMARCA4 (show SMARCA4 Proteins) mutant cancers.

  10. study identifies NO and HDAC2 (show HDAC2 Proteins) nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons

SMARCA2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Gene names and symbols associated with SMARCA2

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog (smarca2.L)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (Smarca2)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (smarca2)
  • 2610209L14Rik protein
  • BAF190 protein
  • Brahma protein
  • brm protein
  • hBRM protein
  • hSNF2a protein
  • NCBRS protein
  • psa-4 protein
  • SNF2 protein
  • SNF2alpha protein
  • Snf2l2 protein
  • SNF2LA protein
  • Sth1p protein
  • SWI2 protein
  • wu:fa56c07 protein
  • wu:fi27f11 protein
  • zgc:66238 protein

Protein level used designations for SMARCA2

ATP-dependent helicase SMARCA2 , BAF190B , BRG1-associated factor 190B , SNF2-alpha , SNF2/SWI2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 , global transcription activator homologous sequence , probable global transcription activator SNF2L2 , protein brahma homolog , sucrose nonfermenting 2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 , subunit of the SWI/SNF chromatin remodeling complex , phasmid Socket Absent PSA-4

GENE ID SPECIES
6595 Homo sapiens
403380 Xenopus laevis
396040 Gallus gallus
67155 Mus musculus
334032 Danio rerio
476335 Canis lupus familiaris
540904 Bos taurus
361745 Rattus norvegicus
100126853 Sus scrofa
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