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The protein encoded by SMARCD2 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Additionally we are shipping SMARCD2 Antibodies (36) and many more products for this protein.
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Data show that both CEBPE (show CEBPE Proteins) and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD (show SGCD Proteins)) abolish the interaction with SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) and secondary granule gene expression, thus providing a molecular basis for this disease.
Defective expression of SMARCD2 (SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins)-related, matrix-associated (show SMARCA5 Proteins), actin-dependent regulator of chromatin, subfamily D, member 2) leads to transcriptional and chromatin changes in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) promyelocytic cells, suggesting SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.
the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
the Rac (show AKT1 Proteins)- and Unkempt-dependent process leading to BAF60b ubiquitination takes place in the nuclear compartment
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2
, 60 kDa BRG-1/Brm-associated factor subunit B
, BRG1-associated factor 60B
, SWI/SNF complex 60 kDa subunit B
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
, Swp73-like protein
, chromatin remodeling complex BAF60B subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60B