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SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1\; MIM 608441) located in the outer nuclear membrane (ONM). Additionally we are shipping SUN2 Proteins (8) and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal SUN2 Primary Antibody for EIA, WB - ABIN955453
Turgay, Ungricht, Rothballer, Kiss, Csucs, Horvath, Kutay: A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane. in The EMBO journal 2010
Show all 2 references for ABIN955453
Mouse (Murine) Monoclonal SUN2 Primary Antibody for ICC, IF - ABIN1042682
Haque, Mazzeo, Patel, Smallwood, Ellis, Shanahan, Shackleton: Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. in The Journal of biological chemistry 2010
Show all 2 references for ABIN1042682
Human Monoclonal SUN2 Primary Antibody for ICC, IF - ABIN1042681
Hodzic, Yeater, Bengtsson, Otto, Stahl: Sun2 is a novel mammalian inner nuclear membrane protein. in The Journal of biological chemistry 2004
Cow (Bovine) Polyclonal SUN2 Primary Antibody for WB - ABIN2782847
Cerhan, Ansell, Fredericksen, Kay, Liebow, Call, Dogan, Cunningham, Wang, Liu-Mares, Macon, Jelinek, Witzig, Habermann, Slager: Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. in Blood 2007
SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer
SUN2 overexpression perturbs both nuclear shape and early events of HIV infection
Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 (show SUN1 Antibodies) and SUN2, as well as the Sec61 (show SEC61A1 Antibodies) translocon complex.
An important role for SUN1 (show SUN1 Antibodies) and SUN2 in muscle disease pathogenesis.
SUN2 as a tumor suppressor mediates miR (show MLXIP Antibodies)-221 and miR (show MLXIP Antibodies)-222 functions in central nervous system embryonal tumors.
Codepletion of SUN1 (show SUN1 Antibodies)/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles.
Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 (show SYNE1 Antibodies) or -2 (the core of the LINC complex).
the crystal structure of the SUN2 protein SUN domain
Data found that expression of lamin A (show LMNA Antibodies) but not lamin C partly restored the nuclear envelope localization of SUN2.
Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM.
our results clearly indicate that SUN1 (show SUN1 Antibodies) and SUN2, at least partially, fulfill redundant meiotic functions
Sun2 has a role in DNA damage response.
Syne-2 (show SYNE2 Antibodies), SUN1 (show SUN1 Antibodies) and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
perturbations in lamin A (show LMNA Antibodies)-SUN1 (show SUN1 Antibodies) and SUN2 protein interactions may underlie the opposing effects of EDMD (show EMD Antibodies) and HGPS (show LMNA Antibodies) mutations on nuclear and cellular mechanics
SUN1 (show SUN1 Antibodies) and SUN2 may form a physical interaction between the nuclear envelope and the centrosome
Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures
These results clearly indicate that SUN1 (show SUN1 Antibodies) and SUN2 function critically in skeletal muscle cells for Syne-1 (show SYNE1 Antibodies) localization at the nuclear envelope, which is essential for proper myonuclear positioning.
indicate that the SUN2-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein (show DYNC1H1 Antibodies)/dynactin (show DCTN1 Antibodies) during neuronal migration.
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1\; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010
SUN domain-containing protein 2
, Sad1 unc-84 domain protein 2
, nuclear envelope protein
, protein unc-84 homolog B
, rab5-interacting protein
, sad1/unc-84 protein-like 2
, unc-84 homolog B