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SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1\; MIM 608441) located in the outer nuclear membrane (ONM). Additionally we are shipping SUN2 Antibodies (32) and many more products for this protein.
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SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer
SUN2 overexpression perturbs both nuclear shape and early events of HIV infection
Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 (show SUN1 Proteins) and SUN2, as well as the Sec61 (show SEC61A1 Proteins) translocon complex.
An important role for SUN1 (show SUN1 Proteins) and SUN2 in muscle disease pathogenesis.
SUN2 as a tumor suppressor mediates miR (show MLXIP Proteins)-221 and miR (show MLXIP Proteins)-222 functions in central nervous system embryonal tumors.
Codepletion of SUN1 (show SUN1 Proteins)/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles.
Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex).
the crystal structure of the SUN2 protein SUN domain
Data found that expression of lamin A (show LMNA Proteins) but not lamin C partly restored the nuclear envelope localization of SUN2.
Data suggest that SUN2 represents the first mammalian inner nuclear membrane (INM) protein relying on a functional nuclear localization signal, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM.
our results clearly indicate that SUN1 (show SUN1 Proteins) and SUN2, at least partially, fulfill redundant meiotic functions
Sun2 has a role in DNA damage response.
Syne-2 (show SYNE2 Proteins), SUN1 (show SUN1 Proteins) and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
perturbations in lamin A (show LMNA Proteins)-SUN1 (show SUN1 Proteins) and SUN2 protein interactions may underlie the opposing effects of EDMD (show EMD Proteins) and HGPS (show LMNA Proteins) mutations on nuclear and cellular mechanics
SUN1 (show SUN1 Proteins) and SUN2 may form a physical interaction between the nuclear envelope and the centrosome
Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures
These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning.
indicate that the SUN2-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein (show DYNC1H1 Proteins)/dynactin (show DCTN1 Proteins) during neuronal migration.
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1\; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010
SUN domain-containing protein 2
, Sad1 unc-84 domain protein 2
, nuclear envelope protein
, protein unc-84 homolog B
, rab5-interacting protein
, sad1/unc-84 protein-like 2
, unc-84 homolog B