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Probable transcription factor.. Additionally we are shipping SALL2 Kits (3) and SALL2 Proteins (3) and many more products for this protein.
Showing 10 out of 17 products:
Sall2 enhanced the p16 (show CDKN2A Antibodies) minigene blocking of cell cycle progression and p16 (show CDKN2A Antibodies) knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression
Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review.
A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice.
The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas.
c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor.
Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1 (show CDKN1A Antibodies)) transcription.
Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth.
A CUL4/DDB1 (show DDB1 Antibodies) E3 ligase containing RBBP7 (show RBBP7 Antibodies) as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state.
Studies indicate that vertebrate sal orthologues (spalt (show SALL1 Antibodies)-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases.
Epidermal growth factor receptor (show EGFR Antibodies) (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas.
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2/Noxa (show PMAIP1 Antibodies) axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Data show that p53 (show TP53 Antibodies) activation diminished SALL2 RNA and protein levels during genotoxic cellular stress in primary embryo fibroblasts (MEFs).
We have now generated mice lacking Sall2.Mice lacking both Sall1 (show SALL1 Antibodies) and Sall2 show kidney phenotypes comparable to those of Sall1 (show SALL1 Antibodies) knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development
Results suggest that p150(Sal2), acting in part as a p53 (show TP53 Antibodies)-independent regulator of p21 (show D4S234E Antibodies) and BAX (show BAX Antibodies), can function in some cell types as a regulator of cell growth and survival.
These data establish Sall2 as a link between p75 neurotrophin receptor (show NGFR Antibodies) and transcriptional events that regulate the growth and development of neuronal cells.
Probable transcription factor.
sal-like protein 2
, zinc finger protein 795
, zinc finger protein SALL2
, zinc finger protein Spalt-2
, spalt-like protein 2