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SALL3 encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. Additionally we are shipping and many more products for this protein.
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Chicken Polyclonal SALL3 Primary Antibody for WB - ABIN2779729
Sweetman, Münsterberg: The vertebrate spalt genes in development and disease. in Developmental biology 2006
Human Polyclonal SALL3 Primary Antibody for ICC, IF - ABIN4351916
de Melo, Peng, Chen, Blackshaw: The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. in Development (Cambridge, England) 2011
sall3 shows aberrant methylation and downregulation in human hepatocellular carcinoma
Studies indicate that vertebrate sal orthologues (spalt (show SALL1 Antibodies)-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases.
This functional characterization of SALL3 sheds light on regulatory mechanisms for DNMT3A (show DNMT3A Antibodies) and provides new strategies to inhibit aberrant methylation in cancer.
Sall3 & TH co-localize in olfactory bulb glomerular layer. Sall3 induces proximal TH promoter transcription. Sall3 deficiency causes reduction of TH expression.
Sall3 plays essential roles in horizontal cell maturation through regulation of neurofilament expression levels
Our findings demonstrate that Sall3 plays a crucial role in regulating the development of both cone photoreceptors and horizontal interneurons. Lhx1 (show LHX1 Antibodies) is one of the most strongly downregulated genes in Sall3 knockout mouse retinas.
The Sall3 locus has aberrant DNA methylation (show HELLS Antibodies) associated with abnormal placental development of cloned mice.
Data suggest that Sall3 is required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives.
Sall3 is required for the terminal maturation of neurons destined for the glomerular layer.
the antagonistic interaction between Hoxa13 (show HOXA13 Antibodies)-Hoxd13 (show HOXD13 Antibodies) and Sall1 (show SALL1 Antibodies)-Sall3 in the developing limb may contribute to the fine-tuning of local Hox (show MSH2 Antibodies) activity that leads to proper morphogenesis of each cartilage element of the vertebrate autopod.
This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.
, zinc finger protein (Xsal-1), homolog of the region specific homeotic gene spalt
, sal-like protein 3
, spalt 2 protein
, C2H2 zinc finger protein SALL3
, spalt-like zinc finger protein
, zinc finger protein 796
, spalt-like protein 3