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inhibits CREB binding and transcription of cAMP-responsive element (CRE)-dependent genes Cyp11A and Star. Additionally we are shipping and Salt-Inducible Kinase 1 Kits (4) and many more products for this protein.
Showing 10 out of 101 products:
Human Monoclonal SIK1 Primary Antibody for IF, IHC (p) - ABIN530988
Hansen, Snow, Tuttle, Ghoneim, Yang, Spencer, Gunter, Smyser, Gurnett, Shinawi, Dobyns, Wheless, Halterman, Jansen, Paschal, Paciorkowski: De novo mutations in SIK1 cause a spectrum of developmental epilepsies. in American journal of human genetics 2015
Chicken Polyclonal SIK1 Primary Antibody for IHC, WB - ABIN2782413
Nishimura, Hayashi, Inada, Tanaka: Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. in Biochemical and biophysical research communications 1999
Human Polyclonal SIK1 Primary Antibody for EIA, WB - ABIN783464
Stephenson, Huang, Huang, Nguyen, Reuter, McBride, Ruiz: snf1lk encodes a protein kinase that may function in cell cycle regulation. in Genomics 2004
Human Polyclonal SIK1 Primary Antibody for IHC (p), WB - ABIN392683
Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. in Science signaling 2009
Human Polyclonal SIK1 Primary Antibody for ELISA, WB - ABIN1533113
Hattori, Fujiyama, Taylor, Watanabe, Yada, Park, Toyoda, Ishii, Totoki, Choi, Groner, Soeda, Ohki, Takagi, Sakaki, Taudien, Blechschmidt, Polley, Menzel, Delabar, Kumpf, Lehmann, Patterson, Reichwald et al.: The DNA sequence of human chromosome 21. ... in Nature 2000
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
SIK1 serves as a part of a self-regulatory circuit to modulate insulin (show INS Antibodies) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D (show PDE4D Antibodies) activity.
Sik1, Sik2 (show SIK2 Antibodies), and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Antibodies) in the liver.
Vascular SIK1 activation may be involved in the prevention of high blood pressure development triggered by high-salt intake through the modulation of the contractile phenotype of VSMCs via transforming growth factor-beta1-signaling inhibition.
SIK1 and SIK3 negatively regulate TLR4 (show TLR4 Antibodies)-mediated signaling through the interruption of TAB2 (show TAB2 Antibodies)-TRAF6 (show TRAF6 Antibodies) complex.
Study shows that knockdown of Sik1 within the suprachiasmatic nuclei results in extended light-induced phase shifts and an enhanced rate of re-entrainment to an advanced light/dark cycle
These results provide evidence that SIK1 is present in lung epithelial cells and that its function is relevant for the action of isoproterenol during regulation of active sodium transport.
Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.
Data provide evidence that sik1 via p57Kip2 (show CDKN1C Antibodies) plays a central role in the time clock mechanism that regulates cardiac cell proliferation and differentiation.
SNF1LK may function G2/M regulation.
Results show a role of SIK1 in gastrin (show GAST Antibodies) induced responses and suggest that SIK1 may act as tumour suppressor in gastric adenocarcinoma cells.
De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
These findings revealed a new function of LKB1 (show STK11 Antibodies) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
SIK1 is required for myogenic differentiation; it's transcriptional regulation and regulated degradation comprise a unified molecular mechanism to precisely tune SIK1 activity in muscle cells.
High SIK gene expression is assiciated with glioblastoma multiforme.
We now demonstrate that TGFbeta (show TGFB1 Antibodies) induces SIK1 levels via a direct transcriptional mechanism that implicates the Smad (show SMAD1 Antibodies) proteins, and we have mapped a putative enhancer element on the SIK1 gene.
activation of the RhoA (show RHOA Antibodies)-ROCK-p38MAPK (show MAPK14 Antibodies)-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D (show CST5 Antibodies) candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells
the basic leucine zipper domain has a role in the regulation of transcriptional activity of CREB (show CREB1 Antibodies) with TORC and salt inducible kinase [review]
SIK is a negative regulator that controls TGFbeta (show TGFB1 Antibodies) receptor turnover and physiological signaling.
inhibits CREB binding and transcription of cAMP-responsive element (CRE)-dependent genes Cyp11A and Star
salt-inducible kinase 1
, serine/threonine-protein kinase SIK1-like
, Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)
, SNF1-like kinase
, myocardial SNF1-like kinase
, salt-inducible protein kinase 1
, serine/threonine-protein kinase SIK1
, serine/threonine-protein kinase SNF1-like kinase 1
, serine/threonine-protein kinase SNF1LK
, qin-induced kinase
, salt-inducible kinase 2
, salt-inducible protein kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, serine/threonine protein kinase
, protein kinase KID2