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anti-Salt-Inducible Kinase 2 (SIK2) Antibodies

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Proteins (9) and SIK2 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIK2 235344 Q8CFH6
SIK2 23235 Q9H0K1
SIK2 315649  
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Top anti-SIK2 Antibodies at antibodies-online.com

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Chimpanzee Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SIK2 Antibody (Center)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SIK2 antibody detected the SIK2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated WB Mouse Sik2 Antibody (Center)  western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Sik2 antibody detected the Sik2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB Human Pancreas (formalin-fixed, paraffin-embedded) stained with SNF1LK2 antibody ABIN239846 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated FACS 100 μg Log in to see 10 to 12 Days
$211.97
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SIK2 / SNF1LK2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959690 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated IF, IP, IHC, WB 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with SNF1LK2 antibody ABIN297633 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

SIK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Human , , ,
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Rat (Rattus)


Top referenced anti-SIK2 Antibodies

  1. Human Monoclonal SIK2 Primary Antibody for FACS - ABIN2666364 : Horike, Takemori, Katoh, Doi, Min, Asano, Sun, Yamamoto, Kasayama, Muraoka, Nonaka, Okamoto: Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN2666364

  2. Human Polyclonal SIK2 Primary Antibody for EIA, WB - ABIN783466 : Shoji, Ito, Shirato, Mizumoto: MZI optical isolator with Si-wire waveguides by surface-activated direct bonding. in Optics express 2012 (PubMed)
    Show all 2 references for ABIN783466

More Antibodies against SIK2 Interaction Partners

Mouse (Murine) Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. SIK2 acts directly on CRTC2 (show CRTC2 Antibodies), CRTC3 (show CRTC3 Antibodies) and HDAC4 (show HDAC5 Antibodies), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Antibodies)-regulated transcription co-activators and PP2A (show PPP2R2B Antibodies). Downstream, SIK2 increases GLUT4 (show SLC2A4 Antibodies) levels and glucose uptake in adipocytes.

  2. Sik1 (show SIK1 Antibodies), Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Antibodies) in the liver.

  3. Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Antibodies)-CREB (show CREB1 Antibodies) function of the white adipocytes.

  4. The SIK2-p35 (show CDK5R1 Antibodies)-PJA2 (show PJA2 Antibodies) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Antibodies)-CDK5 (show CDK5 Antibodies) and the AMPK (show PRKAA1 Antibodies) family in excitable cells.

  5. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  6. These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Antibodies) I/IV, and regulates CREB (show CREB1 Antibodies) via TORC1 (show CRTC1 Antibodies).

  7. SIK2 represses eumelanogenesis in mice.

  8. low SIK2 activity was associated with increased p300 HAT (show EP300 Antibodies) activity, ChREBP (show MLXIPL Antibodies) hyperacetylation, and hepatic steatosis

  9. Results support a role for SIK2 in adipocyte energy metabolism. SIK2 may function similarly to AMPK (show PRKAA1 Antibodies) for turning off lipogenesis in low-energy state.

  10. SIK2-TORC2 (show CRTC2 Antibodies) cascade may be important for the regulation of PGC-1alpha (show PPARGC1A Antibodies) and UCP-1 (show UCP1 Antibodies) gene expression in insulin (show INS Antibodies) signaling in brown adipose tissue

Human Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Antibodies) progression and a negative regulator of CREB1 (show CREB1 Antibodies) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.

  2. this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Antibodies) and CaMKI (show CAMK1 Antibodies) and PME-1 (show PPME1 Antibodies) networks may function in fine-tuning cell proliferation and stress response.

  3. a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Antibodies) contributes to the regulation of ERAD in mammalian cells.

  4. These findings revealed a new function of LKB1 (show STK11 Antibodies) and salt-inducible kinases as negative regulators of HTLV-1 transcription.

  5. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  6. findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.

  7. In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 (show YWHAQ Antibodies) proteins.

  8. Depletion of SIK2 also delayed G1/S transition and reduced AKT (show AKT1 Antibodies) phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers

  9. Increased SIK2 expression is associated with diffuse large B-cell lymphoma.

SIK2 Antigen Profile

Protein Summary

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene names and symbols associated with SIK2

  • salt-inducible kinase 2 (SLK2) antibody
  • salt inducible kinase 2 (Sik2) antibody
  • salt-inducible kinase 2 (SIK2) antibody
  • salt-inducible kinase 2 (Sik2) antibody
  • G630080D20Rik antibody
  • LOH11CR1I antibody
  • QIK antibody
  • RGD1559698 antibody
  • SNF1LK2 antibody

Protein level used designations for SIK2

salt-inducible kinase 2 , SIK-2 , SNF1-like kinase 2 , salt induceable kinase 2 , salt-inducible protein kinase 2 , serine/threonine-protein kinase SIK2 , serine/threonine-protein kinase SNF1-like kinase 2 , qin-induced kinase , salt-inducible serine/threonine kinase 2

GENE ID SPECIES
100189673 Pongo abelii
235344 Mus musculus
23235 Homo sapiens
451540 Pan troglodytes
489410 Canis lupus familiaris
539570 Bos taurus
315649 Rattus norvegicus
768557 Gallus gallus
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