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Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Antibodies (95) and SIK2 Proteins (9) and many more products for this protein.
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SIK2 acts directly on CRTC2 (show CRTC2 ELISA Kits), CRTC3 (show CRTC3 ELISA Kits) and HDAC4 (show HDAC5 ELISA Kits), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 ELISA Kits)-regulated transcription co-activators and PP2A. Downstream, SIK2 increases GLUT4 (show SLC2A4 ELISA Kits) levels and glucose uptake in adipocytes.
Sik1 (show SIK1 ELISA Kits), Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 ELISA Kits) in the liver.
Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 ELISA Kits)-CREB (show CREB1 ELISA Kits) function of the white adipocytes.
The SIK2-p35 (show CDK5R1 ELISA Kits)-PJA2 (show PJA2 ELISA Kits) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 ELISA Kits)-CDK5 (show CDK5 ELISA Kits) and the AMPK (show PRKAA1 ELISA Kits) family in excitable cells.
tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G ELISA Kits) I/IV, and regulates CREB (show CREB1 ELISA Kits) via TORC1 (show CRTC1 ELISA Kits).
SIK2 represses eumelanogenesis in mice.
low SIK2 activity was associated with increased p300 HAT (show EP300 ELISA Kits) activity, ChREBP (show MLXIPL ELISA Kits) hyperacetylation, and hepatic steatosis
Results support a role for SIK2 in adipocyte energy metabolism. SIK2 may function similarly to AMPK (show PRKAA1 ELISA Kits) for turning off lipogenesis in low-energy state.
SIK2-TORC2 (show CRTC2 ELISA Kits) cascade may be important for the regulation of PGC-1alpha (show PPARGC1A ELISA Kits) and UCP-1 (show UCP1 ELISA Kits) gene expression in insulin (show INS ELISA Kits) signaling in brown adipose tissue
Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 ELISA Kits) progression and a negative regulator of CREB1 (show CREB1 ELISA Kits) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 ELISA Kits) and CaMKI (show CAMK1 ELISA Kits) and PME-1 (show PPME1 ELISA Kits) networks may function in fine-tuning cell proliferation and stress response.
a mechanism by which the interplay between SIK2 and p97/VCP (show vcp ELISA Kits) contributes to the regulation of ERAD in mammalian cells.
These findings revealed a new function of LKB1 (show STK11 ELISA Kits) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.
In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 (show YWHAQ ELISA Kits) proteins.
Depletion of SIK2 also delayed G1/S transition and reduced AKT (show AKT1 ELISA Kits) phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers
Increased SIK2 expression is associated with diffuse large B-cell lymphoma.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
salt-inducible kinase 2
, SNF1-like kinase 2
, salt induceable kinase 2
, salt-inducible protein kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, qin-induced kinase
, salt-inducible serine/threonine kinase 2