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Salt-Inducible Kinase 2 Proteins (SIK2)

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Antibodies (92) and SIK2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIK2 235344 Q8CFH6
SIK2 23235 Q9H0K1
Rat SIK2 SIK2 315649  
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Top SIK2 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

SIK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
,
Human , , ,
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More Proteins for Salt-Inducible Kinase 2 (SIK2) Interaction Partners

Mouse (Murine) Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. SIK2 acts directly on CRTC2 (show CRTC2 Proteins), CRTC3 (show CRTC3 Proteins) and HDAC4 (show HDAC5 Proteins), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Proteins)-regulated transcription co-activators and PP2A (show PPP2R2B Proteins). Downstream, SIK2 increases GLUT4 (show SLC2A4 Proteins) levels and glucose uptake in adipocytes.

  2. Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Proteins) in the liver.

  3. Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Proteins)-CREB (show CREB1 Proteins) function of the white adipocytes.

  4. The SIK2-p35 (show CDK5R1 Proteins)-PJA2 (show PJA2 Proteins) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Proteins)-CDK5 (show CDK5 Proteins) and the AMPK (show PRKAA1 Proteins) family in excitable cells.

  5. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  6. These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Proteins) I/IV, and regulates CREB (show CREB1 Proteins) via TORC1 (show CRTC1 Proteins).

  7. SIK2 represses eumelanogenesis in mice.

  8. low SIK2 activity was associated with increased p300 HAT (show EP300 Proteins) activity, ChREBP (show MLXIPL Proteins) hyperacetylation, and hepatic steatosis

  9. Results support a role for SIK2 in adipocyte energy metabolism. SIK2 may function similarly to AMPK (show PRKAA1 Proteins) for turning off lipogenesis in low-energy state.

  10. SIK2-TORC2 (show CRTC2 Proteins) cascade may be important for the regulation of PGC-1alpha and UCP-1 (show UCP1 Proteins) gene expression in insulin (show INS Proteins) signaling in brown adipose tissue

Human Salt-Inducible Kinase 2 (SIK2) interaction partners

  1. Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Proteins) progression and a negative regulator of CREB1 (show CREB1 Proteins) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.

  2. this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 (show PPME1 Proteins) networks may function in fine-tuning cell proliferation and stress response.

  3. a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Proteins) contributes to the regulation of ERAD in mammalian cells.

  4. These findings revealed a new function of LKB1 (show STK11 Proteins) and salt-inducible kinases as negative regulators of HTLV-1 transcription.

  5. tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases

  6. findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.

  7. In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 (show YWHAQ Proteins) proteins.

  8. Depletion of SIK2 also delayed G1/S transition and reduced AKT (show AKT1 Proteins) phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers

  9. Increased SIK2 expression is associated with diffuse large B-cell lymphoma.

SIK2 Protein Profile

Protein Summary

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene names and symbols associated with Salt-Inducible Kinase 2 Proteins (SIK2)

  • salt-inducible kinase 2 (SLK2)
  • salt inducible kinase 2 (Sik2)
  • salt-inducible kinase 2 (SIK2)
  • salt-inducible kinase 2 (Sik2)
  • G630080D20Rik protein
  • LOH11CR1I protein
  • QIK protein
  • RGD1559698 protein
  • SNF1LK2 protein

Protein level used designations for Salt-Inducible Kinase 2 Proteins (SIK2)

salt-inducible kinase 2 , SIK-2 , SNF1-like kinase 2 , salt induceable kinase 2 , salt-inducible protein kinase 2 , serine/threonine-protein kinase SIK2 , serine/threonine-protein kinase SNF1-like kinase 2 , qin-induced kinase , salt-inducible serine/threonine kinase 2

GENE ID SPECIES
100189673 Pongo abelii
235344 Mus musculus
23235 Homo sapiens
451540 Pan troglodytes
489410 Canis lupus familiaris
539570 Bos taurus
315649 Rattus norvegicus
768557 Gallus gallus
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