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Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Antibodies (94) and SIK2 Kits (7) and many more products for this protein.
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SIK2 acts directly on CRTC2 (show CRTC2 Proteins), CRTC3 (show CRTC3 Proteins) and HDAC4 (show HDAC5 Proteins), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Proteins)-regulated transcription co-activators and PP2A (show PPP2R2B Proteins). Downstream, SIK2 increases GLUT4 (show SLC2A4 Proteins) levels and glucose uptake in adipocytes.
Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Proteins) in the liver.
Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Proteins)-CREB (show CREB1 Proteins) function of the white adipocytes.
The SIK2-p35 (show CDK5R1 Proteins)-PJA2 (show PJA2 Proteins) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Proteins)-CDK5 (show CDK5 Proteins) and the AMPK (show PRKAA1 Proteins) family in excitable cells.
tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Proteins) I/IV, and regulates CREB (show CREB1 Proteins) via TORC1 (show CRTC1 Proteins).
SIK2 represses eumelanogenesis in mice.
low SIK2 activity was associated with increased p300 HAT (show EP300 Proteins) activity, ChREBP (show MLXIPL Proteins) hyperacetylation, and hepatic steatosis
Results support a role for SIK2 in adipocyte energy metabolism. SIK2 may function similarly to AMPK (show PRKAA1 Proteins) for turning off lipogenesis in low-energy state.
SIK2-TORC2 (show CRTC2 Proteins) cascade may be important for the regulation of PGC-1alpha and UCP-1 (show UCP1 Proteins) gene expression in insulin (show INS Proteins) signaling in brown adipose tissue
Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Proteins) progression and a negative regulator of CREB1 (show CREB1 Proteins) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 (show PPME1 Proteins) networks may function in fine-tuning cell proliferation and stress response.
a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Proteins) contributes to the regulation of ERAD in mammalian cells.
These findings revealed a new function of LKB1 (show STK11 Proteins) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
findings uncover SIK2 as a critical determinant in autophagy progression and further suggest a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis.
In adipocytes, Ser358 (not Ser587) is the main site phosphorylated and responsible for the binding of SIK2 to 14-3-3 (show YWHAQ Proteins) proteins.
Depletion of SIK2 also delayed G1/S transition and reduced AKT (show AKT1 Proteins) phosphorylation. Higher expression of SIK2 significantly correlated with poor survival in patients with high-grade serous ovarian cancers
Increased SIK2 expression is associated with diffuse large B-cell lymphoma.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
salt-inducible kinase 2
, SNF1-like kinase 2
, salt induceable kinase 2
, salt-inducible protein kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, qin-induced kinase
, salt-inducible serine/threonine kinase 2