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SSPN encodes a member of the dystrophin-glycoprotein complex (DGC). Additionally we are shipping Sarcospan (Kras Oncogene-Associated Gene) Antibodies (16) and Sarcospan (Kras Oncogene-Associated Gene) Proteins (5) and many more products for this protein.
Our data suggest TWIST1 (show TWIST1 ELISA Kits) and SSPN to be the functionally relevant androgenetic alopecia genes at the 7p21.1 and 12p12.1 risk loci, respectively.
When human SSPN is expressed at three-fold levels in mdx mice, this increas (show DMD ELISA Kits)e in adhesion complex abundance improves muscle membrane stability, preventing many of the histopathological changes associa (show DMD ELISA Kits)ted with Duchenne muscular dystrophy
Analysis of sarcospan as a candidate gene for congenital fibrosis of the extraocular muscles type 1.
Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
Sarcospan plays an important mechanical role in stabilizing the dystrophin (show DMD ELISA Kits)-glycoprotein complex.
crystal structure of Imp (show IMPA1 ELISA Kits) beta (127-876) in complex SPN1 (1-65) at 2.8-A resolution reveals that Imp (show IMPA1 ELISA Kits) beta adopts an open conformation, which is unique for a functional Imp (show IMPA1 ELISA Kits) beta/cargo complex, and resembles the conformation of the Imp (show IMPA1 ELISA Kits) beta/RanGTP complex
decreased expression of sarcospan at the Fukuyama congenital muscular dystrophy myofiber surfaces.
Human SSPN in transgegnic mice directly interacts with utrophin (show UTRN ELISA Kits)-glycoprotein comlpex and functions to stabilize utrophin (show UTRN ELISA Kits) protein without increasing utrophin (show UTRN ELISA Kits) transcription.
these results demonstrate that SSPN overexpression is well tolerated in mdx (show DMD ELISA Kits) mice and improves sarcolemma defects that underlie skeletal muscle and pulmonary dysfunction in Duchenne muscular dystrophy (show DMD ELISA Kits)
regulates cardiac isoproterenol response and prevents Duchenne muscular dystrophy (show DMD ELISA Kits)-associated cardiomyopathy
Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin (show UTRN ELISA Kits) and alpha7beta1 integrin.
SSPN is a necessary component of dystrophin (show DMD ELISA Kits) and Utr (show UTS2R ELISA Kits) function and that SSPN modulation of integrin signaling is required for extracellular matrix attachment and muscle force development.
Sarcospan-null mice displayed delayed differentiation after cardiotoxin injury caused by loss of utrophin (show UTRN ELISA Kits) and Akt (show AKT1 ELISA Kits) signaling
Sspn is downregulated in brain during hypoxia. Knockdown of Sspn increased cultured cell death under hypoxia.
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.
sarcospan (Kras oncogene-associated gene)
, K-ras oncogene-associated protein
, Kras oncogene-associated
, kirsten-ras-associated protein
, kirsten-Ras-associated protein