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SSPN encodes a member of the dystrophin-glycoprotein complex (DGC). Additionally we are shipping Sarcospan (Kras Oncogene-Associated Gene) Antibodies (16) and many more products for this protein.
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Analysis of sarcospan as a candidate gene for congenital fibrosis of the extraocular muscles type 1.
Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
Sarcospan plays an important mechanical role in stabilizing the dystrophin (show DMD Proteins)-glycoprotein complex.
crystal structure of Imp (show IMPA1 Proteins) beta (127-876) in complex SPN1 (1-65) at 2.8-A resolution reveals that Imp (show IMPA1 Proteins) beta adopts an open conformation, which is unique for a functional Imp (show IMPA1 Proteins) beta/cargo complex, and resembles the conformation of the Imp (show IMPA1 Proteins) beta/RanGTP complex
decreased expression of sarcospan at the Fukuyama congenital muscular dystrophy myofiber surfaces.
Human SSPN in transgegnic mice directly interacts with utrophin-glycoprotein comlpex and functions to stabilize utrophin protein without increasing utrophin transcription.
regulates cardiac isoproterenol response and prevents Duchenne muscular dystrophy (show DMD Proteins)-associated cardiomyopathy
Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.
SSPN is a necessary component of dystrophin (show DMD Proteins) and Utr function and that SSPN modulation of integrin signaling is required for extracellular matrix attachment and muscle force development.
Sarcospan-null mice displayed delayed differentiation after cardiotoxin injury caused by loss of utrophin and Akt (show AKT1 Proteins) signaling
Sspn is downregulated in brain during hypoxia. Knockdown of Sspn increased cultured cell death under hypoxia.
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.
sarcospan (Kras oncogene-associated gene)
, K-ras oncogene-associated protein
, Kras oncogene-associated
, kirsten-ras-associated protein
, kirsten-Ras-associated protein