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Scavenger Receptor Class B, Member 2 Proteins (SCARB2)

The protein encoded by SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Additionally we are shipping SCARB2 Antibodies (66) and SCARB2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCARB2 950 Q14108
SCARB2 12492 O35114
Rat SCARB2 SCARB2 117106 P27615
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Top SCARB2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Human Un-conjugated Human recombinant SCARB2 / CD36L2 / LIMP2. The purity of rh SCARB2 /CD36L2 /LlMP2 was determined by DTT-reduced (+) SDSPAGE and staining overnight with Coomassie Blue. 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

SCARB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , ,
Mouse (Murine) , ,
,

Top referenced SCARB2 Proteins

  1. Human SCARB2 Protein expressed in HEK-293 Cells - ABIN2181727 : Reczek, Schwake, Schröder, Hughes, Blanz, Jin, Brondyk, Van Patten, Edmunds, Saftig: LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. in Cell 2007 (PubMed)
    Show all 3 references for ABIN2181727

More Proteins for Scavenger Receptor Class B, Member 2 (SCARB2) Interaction Partners

Human Scavenger Receptor Class B, Member 2 (SCARB2) interaction partners

  1. Findings suggested that STX1B (show STX1B Proteins) rs4889603, FAM47E rs6812193 and SCARB2 rs6825004 do not confer a significant risk for Parkinson's disease

  2. LIMPII was increased greater than twofold in urinary microvesicles obtained from patients with idiopathic membranous nephropathy compared to microvesicles of patients with idiopathic focal segmental glomerulosclerosis and normal controls.

  3. hSR-BII (show CACNA1E Proteins), and to a lesser extent hSR-BI, significantly increase LPS (show IRF6 Proteins)-induced inflammation and contribute to LPS (show IRF6 Proteins)-induced tissue injury in the liver and kidney, two major organs susceptible to LPS (show IRF6 Proteins) toxicity.

  4. Although hrGCase cellular uptake is independent of LIMP-2, its trafficking to the lysosomes is mediated by this receptor.

  5. SNCA and SCARB2 loci are also associated with dementia with Lewy bodies, after a study-wise Bonferroni correction, although these have a different association profile than the associations reported for the same loci in Parkinson's.

  6. a novel mutation in SCARB2 as a cause of progressive myoclonus epilepsy in China

  7. SCARB2 regulates TLR9 (show TLR9 Proteins)-dependent IFN-I production of plasmacytoid dendritic cells

  8. Disease-causing cathepsin-F (show CTSF Proteins) mutants fail to cleave LIMP-2. Our findings provide evidence that LIMP-2 represents an in vivo substrate of cathepsin-F (show CTSF Proteins) with relevance for understanding the pathophysiology of type-B-Kufs-disease.

  9. Data indicate that scavenger receptor SCARB2 triggers uncoating of human enterovirus 71 (EV71) under low pH conditions.

  10. SCARB2 and PSGL-1 (show SELPLG Proteins) in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection.

Mouse (Murine) Scavenger Receptor Class B, Member 2 (SCARB2) interaction partners

  1. AP-3 (show AP3B1 Proteins)-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 (show PRDX6 Proteins) in vitro and in vivo

  2. Heterologous expression of the luminal domain of LIMP-2 in wild-type cells.

  3. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation.

  4. absence of Limp-2 reduces inflammation in experimental crescentic glomerulonephritis with decreased macrophage and T-cell infiltration in the kidney.

  5. Limp-2 deficiency leads to a minor increase in circulating renin (show REN Proteins). Limp-2, however, is not required for acute or chronic stimulation of renin (show REN Proteins) release.

  6. The SR-BII is involved in cholesterol ester uptake for steroidogenesis and spermatogenesis in the testis.

  7. The residues between 144 and 151 are critical for SCARB2 binding to VP1 of EV71 and seven residues from the human receptor could convert murine SCARB2, an otherwise inefficient receptor, to an efficient receptor for EV71 viral infection.

  8. The data suggest that tubular proteinuria in Limp-2(-/-) mice is due to failure of endosomes containing reabsorbed proteins to fuse with lysosomes in the proximal tubule of the kidney. Failure of proteolysis is a novel mechanism for tubular proteinuria.

  9. The coiled-coil structure of LIMP-2 is required for its interaction with beta-glucocerebrosidase (show GBA Proteins).

  10. CD36 is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells.

SCARB2 Protein Profile

Protein Summary

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCARB2

  • scavenger receptor class B, member 2 (scarb2)
  • scavenger receptor class B, member 2 (SCARB2)
  • scavenger receptor class B, member 2 (Scarb2)
  • 9330185J12Rik protein
  • AMRF protein
  • Cd36l2 protein
  • chunp6914 protein
  • EPM4 protein
  • fi13c07 protein
  • HLGP85 protein
  • LGP85 protein
  • LIMP-2 protein
  • LimpII protein
  • MLGP85 protein
  • scarb2 protein
  • SR-BII protein
  • wu:fi13c07 protein

Protein level used designations for SCARB2

CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 , CD36 antigen-like 2 , lysosome membrane protein 2 , scavenger receptor class B, member 2 , lysosome membrane protein 2-like , putative lysosomal integral membrane protein II , 85 kDa lysosomal membrane sialoglycoprotein , 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2 , CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) , LIMP II , lysosome membrane protein II

GENE ID SPECIES
192340 Danio rerio
422638 Gallus gallus
461239 Pan troglodytes
549311 Xenopus (Silurana) tropicalis
699990 Macaca mulatta
100026052 Monodelphis domestica
100455864 Pongo abelii
100190617 Taeniopygia guttata
100397594 Callithrix jacchus
100470627 Ailuropoda melanoleuca
100593903 Nomascus leucogenys
533177 Bos taurus
950 Homo sapiens
12492 Mus musculus
117106 Rattus norvegicus
478435 Canis lupus familiaris
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