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SCXA encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. Additionally we are shipping Scleraxis Homolog A (Mouse) Antibodies (19) and and many more products for this protein.
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The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Proteins)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes
Cardiac fibroblast phenotype regulation by scleraxis.
scleraxis, a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of mesenchymal stem cells towards tenocyte differentiation.
deletion of Scx led to impairments in enthesis structure.
several mRNAs are affected by alternative splicing events in the absence of Scx, suggesting additional roles in post-transcriptional modification.
Expression and function of scleraxis in the developing auditory system.
These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells.
paratenon cells, which normally do not express Scx, respond to injury by turning on Scx and assembling matrix to bridge the defect
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
Findings suggest a modular model for bone development, involving a distinct pool of Sox9 (show SOX9 Proteins)- and Scx-positive progenitor cells that form bone eminences under regulation of TGFbeta (show TGFB1 Proteins) and BMP4 (show BMP4 Proteins) signaling
This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction.
basic helix-loop-helix transcription factor scleraxis
, class A basic helix-loop-helix protein 41
, class A basic helix-loop-helix protein 48
, class II bHLH protein scleraxis