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Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages (By similarity)..
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Abnormal upregulation of HIF-2alpha served as a key switch to direct TSPCs differentiation into osteochondral-lineage rather than teno-lineage. Notably, Scleraxis (Scx), an essential tendon specific transcription factor, was suppressed on constitutive activation of HIF-2alpha and mediated the effect of HIF-2alpha on TSPCs fate decision.
These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells.
Scleraxis was expressed in periodontal ligament cells, bone marrow cells, and gingival fibroblasts, and may play an important role in differentiation of periodontal ligament cells.
High glucose inhibited osteogenetic differentiation of periodontal ligament cells and up-regulated Scleraxis expression.
Scx and E47 (show TCF3 ELISA Kits) might modulate the primary chondrogenesis by associating with the Sox9 (show SOX9 ELISA Kits)-related transcriptional complex, and by binding to the conserved E-box on Col2a1 (show COL2A1 ELISA Kits) promoter.
collagen type I and several T/L-related proteoglycans were upregulated in hMSC-Scx cells
Scleraxis thus appears to play a key role in the transcriptional regulation of type I collagen synthesis.
Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages (By similarity).
basic helix-loop-helix transcription factor scleraxis
, class A basic helix-loop-helix protein 41
, class A basic helix-loop-helix protein 48