anti-Sclerostin (SOST) Antibodies

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Kits (54) and Sclerostin Proteins (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top anti-Sclerostin Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-SOST Antibody (N-term) Pab (ABIN390193) in mouse liver tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term)(ABIN390193), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of SOST Antibody (Center) (ABIN390194) in mouse lung tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center)(ABIN390194), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SOST Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SOST antibody detected the SOST protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Goat Un-conjugated IHC, WB 100 μg Log in to see 7 to 9 Days
$815.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated (ABIN1714867) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse lung probed with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated  at 1:5000 for 90 min at 37˚C. 100 μL Log in to see 14 to 21 Days
$295.90
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of HeLa and HepG2 cell lines, using SOST antibody. Immunohistochemistry of paraffin-embedded human prostate using SOST antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$323.13
Details

SOST Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sclerostin Antibodies

  1. Human Polyclonal Sclerostin Primary Antibody for IHC (p), WB - ABIN390193 : Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. in The Journal of biological chemistry 2006 (PubMed)
    Show all 2 references for 390193

  2. Human Polyclonal Sclerostin Primary Antibody for EIA, IHC (p) - ABIN358751 : Ellies, Viviano, McCarthy, Rey, Itasaki, Saunders, Krumlauf: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 (PubMed)
    Show all 2 references for 358751

More Antibodies against Sclerostin Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.

  2. Intermittent compressive stress regulates Notch (show NOTCH1 Antibodies) receptor and target gene expression via the TGF-beta (show TGFB1 Antibodies) signaling pathway. Notch (show NOTCH1 Antibodies) signaling participates in TGF-beta (show TGFB1 Antibodies)-induced sclerostin expression in periodontal ligament cells.

  3. Dickkopf-1 (show DKK1 Antibodies) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.

  4. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  5. Circulating sclerostin and Dickkopf-1 (show DKK1 Antibodies) levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  6. SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (show WNT2 Antibodies)clerosis, possibly because of epigenetic silencing.

  7. The level of sclerostin was higher in the female obstructive sleep apnea (OSA) patients than that in female controls. Further, in OSA women with cardiovascular comorbidities, sclerostin was higher than in women without such comorbidities. In men, there were no differences in the serum sclerostin level between the OSA and control subjects, nor was there any relationship with cardiovascular diseases.

  8. Knockdown of SOST in MG-63 cells increases osteogenesis and ratio of OPG/RANKL (show TNFSF11 Antibodies) in vitro

  9. The findings confirm that the human SOST gene and sclerostin expression can be considered to be directly 1,25-dihydroxyvitamin D-responsive in osteocytes.

  10. Our study highlighted the high serum levels of DKK-1 (show DKK1 Antibodies) and sclerostin in T1DM children and their relationship with altered glycemic control

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  2. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  3. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (show WNT2 Antibodies) signaling pathway inhibition.

  4. Analysis of SOST expression using large minigenes reveals the MEF2C (show MEF2C Antibodies) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (show TGFB1 Antibodies) responsiveness.

  5. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  6. chronic TNFalpha (tumor necrosis factor alpha (show TNF Antibodies))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  7. Data show that the phenotype of Notch (show NOTCH1 Antibodies) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 Antibodies))-Cre;Rosa(Notch (show NOTCH1 Antibodies)) mice hemizygous for the Dmp1 (show DMP1 Antibodies)-sclerostin (SOST) transgene.

  8. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (show TAZ Antibodies)-responsive transcriptional activity and TAZ (show TAZ Antibodies)-responsive gene expression, indicating a role for TAZ (show TAZ Antibodies) as a regulator of adipogenesis by sclerostin.

  9. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  10. Sclerostin depletion enhances tibial fracture healing.

Sclerostin (SOST) Antigen Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with anti-Sclerostin (SOST) Antibodies

  • sclerostin (LOC100313724) antibody
  • sclerostin (SOST) antibody
  • sclerostin (Sost) antibody
  • sclerostin-like (LOC100513306) antibody
  • 5430411E23Rik antibody
  • CDD antibody
  • LOC100313724 antibody
  • VBCH antibody

Protein level used designations for anti-Sclerostin (SOST) Antibodies

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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