Sclerostin Proteins (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (128) and Sclerostin Kits (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Sclerostin Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Log in to see 2 to 3 Days
$1,375.00
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Mammalian Cells Mouse His tag   10 μg Log in to see 4 Days
$213.68
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,440.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,451.17
Details

SOST Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine) , ,
,
Rat (Rattus) ,

More Proteins for Sclerostin (SOST) Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. observed an association between sclerostin levels with fasting insulin (show INS Proteins) levels and homoeostatic model assessment-insulin (show INS Proteins) resistance, but there was no clear association with type 2 diabetes risk.

  2. Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (show EGFR Proteins). Its involvement with other hormones of mineral homeostasis (FGF23 (show FGF23 Proteins)/Klotho (show KL Proteins) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney

  3. In chronic kidney disease, serum levels of the Wnt (show WNT2 Proteins) inhibitors DKK1 (show DKK1 Proteins) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (show DKK1 Proteins), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (show DPEP1 Proteins)), particularly in dialysis patients.

  4. Vitamin D receptor (show VDR Proteins) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.

  5. SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.

  6. Intermittent compressive stress regulates Notch (show NOTCH1 Proteins) receptor and target gene expression via the TGF-beta (show TGFB1 Proteins) signaling pathway. Notch (show NOTCH1 Proteins) signaling participates in TGF-beta (show TGFB1 Proteins)-induced sclerostin expression in periodontal ligament cells.

  7. Dickkopf-1 (show DKK1 Proteins) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.

  8. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  9. Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  10. SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (show WNT2 Proteins)clerosis, possibly because of epigenetic silencing.

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  2. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  3. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (show WNT2 Proteins) signaling pathway inhibition.

  4. Analysis of SOST expression using large minigenes reveals the MEF2C (show MEF2C Proteins) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (show TGFB1 Proteins) responsiveness.

  5. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  6. chronic TNFalpha (tumor necrosis factor alpha (show TNF Proteins))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  7. Data show that the phenotype of Notch (show NOTCH1 Proteins) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 Proteins))-Cre;Rosa(Notch (show NOTCH1 Proteins)) mice hemizygous for the Dmp1 (show DMP1 Proteins)-sclerostin (SOST) transgene.

  8. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (show TAZ Proteins)-responsive transcriptional activity and TAZ (show TAZ Proteins)-responsive gene expression, indicating a role for TAZ (show TAZ Proteins) as a regulator of adipogenesis by sclerostin.

  9. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  10. Sclerostin depletion enhances tibial fracture healing.

Sclerostin (SOST) Protein Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin Proteins (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • sclerostin-like (LOC100513306)
  • 5430411E23Rik protein
  • CDD protein
  • LOC100313724 protein
  • VBCH protein

Protein level used designations for Sclerostin Proteins (SOST)

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
Selected quality suppliers for Sclerostin Proteins (SOST)
Did you look for something else?