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Sclerostin Proteins (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (97) and Sclerostin Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_HEK-293 Cells Human His tag,Biotin Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Log in to see 2 to 3 Days
$1,375.00
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Human Human His tag   10 μg Log in to see 11 Days
$300.00
Details
HOST_Mammalian Cells Mouse His tag   10 μg Log in to see 5 Days
$242.55
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,440.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details

SOST Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) , ,
,
Rat (Rattus) ,

Top referenced Sclerostin Proteins

  1. Human Sclerostin Protein expressed in Human Cells - ABIN2003109 : Brunkow, Gardner, Van Ness, Paeper, Kovacevich, Proll, Skonier, Zhao, Sabo, Fu, Alisch, Gillett, Colbert, Tacconi, Galas, Hamersma, Beighton, Mulligan: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. in American journal of human genetics 2001 (PubMed)
    Show all 5 references for ABIN2003109

  2. Rat (Rattus) Sclerostin Protein expressed in Human Cells - ABIN2009022 : Balemans, Ebeling, Patel, Van Hul, Olson, Dioszegi, Lacza, Wuyts, Van Den Ende, Willems, Paes-Alves, Hill, Bueno, Ramos, Tacconi, Dikkers, Stratakis, Lindpaintner, Vickery, Foernzler, Van Hul: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). in Human molecular genetics 2001 (PubMed)
    Show all 5 references for ABIN2009022

More Proteins for Sclerostin (SOST) Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. Our study highlighted the high serum levels of DKK-1 (show DKK1 Proteins) and sclerostin in T1DM children and their relationship with altered glycemic control

  2. Sclerostin is an osteocyte marker that is strongly expressed in human woven and lamellar bone and mineralizing chondrocytes

  3. similar levels in type 1 diabetes patients and controls; decrease concurrent with adolescent growth spurt (show BPIFA1 Proteins)

  4. Findings indicate that sclerostin expression is closely associated with the degree of joint damage in primary knee osteoarthritis (OA), confirming its involvement in the development of OA.

  5. Results suggest that sclerostin may have a role in the development of or the response to abdominal aortic calcification in chronic kidney disease.

  6. while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 levels.

  7. serum sclerostin levels were lower in nonalcoholic steatohepatitis patients than in controls.

  8. The aim of this study was to evaluate the renal handling of sclerostin.

  9. Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine.

  10. chronic TNFalpha (tumor necrosis factor alpha (show TNF Proteins))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  2. chronic TNFalpha (tumor necrosis factor alpha (show TNF Proteins))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  3. Data show that the phenotype of Notch (show NOTCH1 Proteins) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 Proteins))-Cre;Rosa(Notch (show NOTCH1 Proteins)) mice hemizygous for the Dmp1 (show DMP1 Proteins)-sclerostin (SOST) transgene.

  4. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (show TAZ Proteins)-responsive transcriptional activity and TAZ (show TAZ Proteins)-responsive gene expression, indicating a role for TAZ (show TAZ Proteins) as a regulator of adipogenesis by sclerostin.

  5. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  6. Sclerostin depletion enhances tibial fracture healing.

  7. SOST gene is involved in the regulation of renal interstitial fibrosis (RIF) progression. In obstructive kidney injury, SOST gene deletion would probably enhance renal fibrogenic response and promote the progression of RIF.

  8. Data (including data from studies in knockout/transgenic mice) suggest that Lrp6 (lipoprotein receptor-related protein 6 (show LRP6 Proteins)) is required for suppression of Sost expression by parathyroid hormone (show PTH Proteins) (here, human PTH (show PTH Proteins) peptide 1-34).

  9. These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 Proteins)-causing mutations, and imply that HBM LRP5 (show LRP5 Proteins) receptors differ in their relative sensitivity to inhibition by SOST and DKK1 (show DKK1 Proteins).

  10. These findings indicated that AMPK (show PRKAA1 Proteins) regulated RANKL (show TNFSF11 Proteins) and sclerostin expression through the mevalonate pathway in osteocytes.

Sclerostin (SOST) Protein Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin Proteins (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • sclerostin-like (LOC100513306)
  • 5430411E23Rik protein
  • CDD protein
  • LOC100313724 protein
  • VBCH protein

Protein level used designations for Sclerostin Proteins (SOST)

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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