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Scribbled Homolog (Drosophila) (SCRIB) ELISA Kits

SCRIB encodes a protein that was identified as being similar to the Drosophila scribble protein. Additionally we are shipping SCRIB Antibodies (27) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SCRIB 105782 Q80U72
Anti-Human SCRIB SCRIB 23513 Q14160
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Top SCRIB ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Mouse 7.81 pg/ml 31.25-2000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for SCRIB Interaction Partners

Fruit Fly (Drosophila melanogaster) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.

  2. Loss of scrib, dlg (show DLG4 ELISA Kits) and lgl had no effect on gonad formation, but Dlg (show DLG4 ELISA Kits) and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  3. Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions.

  4. Loss of Scrib promotes Yorkie (show YAP1 ELISA Kits)/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf (show RAF1 ELISA Kits) signaling.

  5. Data show that mutations causing the loss of Salvador (Sav (show SAV1 ELISA Kits)) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules.

  6. interaction between Ras(V12) and scrib(-) clones involves JNK (show MAPK8 ELISA Kits) signalling propagation and JNK (show MAPK8 ELISA Kits)-induced upregulation of JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits)-activating cytokines, a compensatory growth mechanism for tissue homeostasis

  7. These results demonstrate distinct aPKC and JNK (show MAPK8 ELISA Kits)-dependent pathways through which loss of Scrib promotes tumourigenesis in Drosophila.

  8. Study provide evidence that scrib and dlg (show DLG4 ELISA Kits) function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg (show DLG4 ELISA Kits) act in a common pathway to regulate PFC (show CFP ELISA Kits) fate induction.

  9. conclude that Dlg (show DLG4 ELISA Kits)/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts

  10. Scrib is essential for olfactory behavior in D. melanogaster.

Mouse (Murine) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.

  2. The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

  3. Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.

  4. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1.

  5. The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium.

  6. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

  7. findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (show MAPK1 ELISA Kits)/Fra1 (show FOSL1 ELISA Kits) pathway that alters mammary progenitor activity

  8. The Scribble knockout fetus exhibits exomphalos (intact and ruptured), in contrast to the original published phenotype of gastroschisis.

  9. Scrib is required to maintain epithelial identity and that loss of Scrib can culminate in EMT (show ITK ELISA Kits), mediated, at least in part, through TGFbeta (show TGFB1 ELISA Kits) signaling.

  10. B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation (show BLNK ELISA Kits) and differentiation.

Zebrafish Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.

  2. Suppression of scrib and puf60 in zebrafish (show PUF60 ELISA Kits)leads to reduction in body length, small head size, and craniofacial defects.

  3. It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.

  4. Lpp interacts with the PCP (show PRCP ELISA Kits) protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.

  5. Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates

Human Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. loss of Scribble-induced HuR (show ELAVL1 ELISA Kits) translocation mediates the accumulation of Snail (show SNAI1 ELISA Kits) via activation of the p38 MAPK (show MAPK14 ELISA Kits) pathway.

  2. The two PDZ (show INADL ELISA Kits) domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a 'front-to-back' mode to form a compact supramodule.

  3. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

  4. High levels of mislocalized SCRIB functions as a neomorph to promote mammary tumorigenesis.

  5. miR (show MLXIP ELISA Kits)-296-5p/SCRIB axis plays a role in breast carcinogenesis

  6. This study demonstrated that rare deleterious mutations of SCRIB may contribute to the multifactorial risk for human spina bifida.

  7. These data suggests a novel role for Scribble in positively regulating tight junction assembly through transcriptional regulation of an epithelial-to-mesenchymal signaling program.

  8. SHOC2 (show SHOC2 ELISA Kits) and MRAS (show MRAS ELISA Kits) form a complex with SCRIB.

  9. Although the Scribble P305L mislocalization mutant can no longer suppress Ras-MAPK (show MAPK1 ELISA Kits)-induced invasion or epithelial to mesenchymal transition phenotypes, mislocalized Scribble can still suppress anchorage-independent cell growth.

  10. CD74 (show CD74 ELISA Kits)-dependent deregulation of the tumor suppressor Scribble in human epithelial and breast cancer cells.

SCRIB Antigen Profile

Antigen Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Gene names and symbols associated with SCRIB

  • scribbled (scrib) antibody
  • scribbled homolog (Drosophila) (Scrib) antibody
  • scribbled homolog (Drosophila) (scrib) antibody
  • scribbled planar cell polarity protein (SCRIB) antibody
  • 0424/05 antibody
  • AI118201 antibody
  • CG5462 antibody
  • CG5467 antibody
  • CG31082 antibody
  • CG42614 antibody
  • CG43398 antibody
  • Crc antibody
  • CRIB antibody
  • CRIB1 antibody
  • CT17324 antibody
  • Dmel\\CG43398 antibody
  • Dmel_CG5462 antibody
  • Dmel_CG5467 antibody
  • Dmel_CG31082 antibody
  • Dmel_CG42614 antibody
  • ird antibody
  • ird15 antibody
  • l(3)673 antibody
  • l(3)c00119 antibody
  • l(3)j7B3 antibody
  • l(3)S042405 antibody
  • MENE (3R)-F antibody
  • mKIAA0147 antibody
  • Scb antibody
  • SCR antibody
  • scrb antibody
  • SCRB1 antibody
  • Scrib antibody
  • SCRIB1 antibody
  • scribble antibody
  • scribble1 antibody
  • si:ch211-12p8.1 antibody
  • si:zc12p8.1 antibody
  • smi97B antibody
  • vart antibody
  • Vartul antibody

Protein level used designations for SCRIB

CG43398-PA , CG43398-PB , CG43398-PC , CG43398-PD , CG43398-PH , CG43398-PI , CG43398-PJ , CG43398-PK , CG43398-PL , CG43398-PM , CG43398-PN , CG43398-PO , CG43398-PP , CG43398-PQ , CG43398-PR , CG43398-PS , CG43398-PT , CG43398-PU , CG43398-PX , gp150-like , immune response deficient 15 , lethal (3) c00119 , scrib-PA , scrib-PB , scrib-PC , scrib-PD , scrib-PH , scrib-PI , scrib-PJ , scrib-PK , scrib-PL , scrib-PM , scrib-PN , scrib-PO , scrib-PP , scrib-PQ , scrib-PR , scrib-PS , scrib-PT , scrib-PU , scrib-PX , scribble , scribbles , smell impaired 97B , vartul , PDZ-domain protein scribble , circletail , protein scribble homolog , scribble homolog 1 , landlocked , llk , scribbled homolog

GENE ID SPECIES
44448 Drosophila melanogaster
105782 Mus musculus
368473 Danio rerio
23513 Homo sapiens
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