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SPP2 encodes a secreted phosphoprotein that is a member of the cystatin superfamily. Additionally we are shipping SPP2 Kits (17) and SPP2 Antibodies (15) and many more products for this protein.
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proteolytic processing of spp24 affects the interaction of this protein with BMP-2 (show BMP2 Proteins) and this affects the function of the protein
the two mutations of SPP2 have dominant negative effects and cellular accumulation of Spp-24 might be particularly toxic to photoreceptors and/or retinal pigment epithelium. SPP2 has a new role in retinal degeneration.
Report describes a C-terminal fragment within SPP24 that is distinct from the cystatin (show CST3 Proteins) domain and which independently binds to BMP-2 (show BMP2 Proteins) and TGF-beta (show TGFB1 Proteins). This fragment inhibited BMP-2 (show BMP2 Proteins) activity in an ectopic bone forming assay.
Spp24, or proteolytic products of Spp24, bind cytokines of the TGF-beta (show TGFB1 Proteins) superfamily and also activate intracellular signaling pathways [review]
Spp24 truncation products have effects on osteoblastic differentiation mediated by kinase pathways that are independent of exogenous BMP/TGF-beta (show TGFb Proteins) cytokines.
Results describe the localization of the human secreted phosphoprotein 24 gene, its structure and the start of transcription in liver.
spp24 contains at least 2 single nucleotide polymorphisms. Given its mechanism of action and sequence variability, SPP24 may be an interesting candidate for future studies of the genetic regulation of bone mass.
We report here for the first time the direct isolation of Spp24 covalently bound to alpha2-macroglobulins as a core complex (Spp24-alpha2M) from bovine calf serum.
The beta-pleated sheets of recombinant spp24 play a greater role in bone morphogenetic protein (BMP)-2 binding than does the alpha-helical turn.
levels of spp24 in bone may be regulated, in part, by calcium-dependent proteolysis mediated by osteoblastic cells
This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily.
secreted phosphoprotein 24
, secreted phosphoprotein 2
, secreted phosphoprotein 2, 24kDa
, growth hormone regulated gene-1