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Secreted Phosphoprotein 2 Proteins (SPP2)

SPP2 encodes a secreted phosphoprotein that is a member of the cystatin superfamily. Additionally we are shipping SPP2 Kits (23) and SPP2 Antibodies (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPP2 75396 Q8K1I3
Rat SPP2 SPP2 94168 Q62740
SPP2 6694 Q13103
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Top SPP2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,370.50
Details
Yeast Oncorhynchus mykiss His tag   1 mg Log in to see 56 to 66 Days
$2,405.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,423.67
Details

SPP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Secreted Phosphoprotein 2 (SPP2) Interaction Partners

Mouse (Murine) Secreted Phosphoprotein 2 (SPP2) interaction partners

  1. proteolytic processing of spp24 affects the interaction of this protein with BMP-2 (show BMP2 Proteins) and this affects the function of the protein

Human Secreted Phosphoprotein 2 (SPP2) interaction partners

  1. the two mutations of SPP2 have dominant negative effects and cellular accumulation of Spp-24 might be particularly toxic to photoreceptors and/or retinal pigment epithelium. SPP2 has a new role in retinal degeneration.

  2. Report describes a C-terminal fragment within SPP24 that is distinct from the cystatin (show CST3 Proteins) domain and which independently binds to BMP-2 (show BMP2 Proteins) and TGF-beta (show TGFB1 Proteins). This fragment inhibited BMP-2 (show BMP2 Proteins) activity in an ectopic bone forming assay.

  3. Spp24, or proteolytic products of Spp24, bind cytokines of the TGF-beta (show TGFB1 Proteins) superfamily and also activate intracellular signaling pathways [review]

  4. Spp24 truncation products have effects on osteoblastic differentiation mediated by kinase pathways that are independent of exogenous BMP/TGF-beta (show TGFb Proteins) cytokines.

  5. Results describe the localization of the human secreted phosphoprotein 24 gene, its structure and the start of transcription in liver.

  6. spp24 contains at least 2 single nucleotide polymorphisms. Given its mechanism of action and sequence variability, SPP24 may be an interesting candidate for future studies of the genetic regulation of bone mass.

Cow (Bovine) Secreted Phosphoprotein 2 (SPP2) interaction partners

  1. We report here for the first time the direct isolation of Spp24 covalently bound to alpha2-macroglobulins as a core complex (Spp24-alpha2M) from bovine calf serum.

  2. The beta-pleated sheets of recombinant spp24 play a greater role in bone morphogenetic protein (BMP)-2 binding than does the alpha-helical turn.

  3. levels of spp24 in bone may be regulated, in part, by calcium-dependent proteolysis mediated by osteoblastic cells

SPP2 Protein Profile

Protein Summary

This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily.

Gene names and symbols associated with SPP2

  • secreted phosphoprotein 24 (spp2)
  • secreted phosphoprotein 2 (Spp2)
  • secreted phosphoprotein 2, 24kDa (SPP2)
  • 0610038O04Rik protein
  • GHRG-1 protein
  • pp-24 protein
  • SPP-24 protein
  • SPP24 protein

Protein level used designations for SPP2

secreted phosphoprotein 24 , spp-24 , secreted phosphoprotein 2 , secreted phosphoprotein 2, 24kDa , growth hormone regulated gene-1

GENE ID SPECIES
100136400 Salmo salar
75396 Mus musculus
94168 Rattus norvegicus
6694 Homo sapiens
281500 Bos taurus
396080 Gallus gallus
396669 Sus scrofa
443510 Ovis aries
100136098 Oncorhynchus mykiss
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