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SPARC encodes a cysteine-rich acidic matrix-associated protein. Additionally we are shipping SPARC Antibodies (172) and SPARC Kits (57) and many more products for this protein.
Showing 10 out of 44 products:
Human SPARC Protein expressed in Escherichia coli (E. coli) - ABIN1047668
Lankat-Buttgereit, Mann, Deutzmann, Timpl, Krieg: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). in FEBS letters 1988
Mouse (Murine) SPARC Protein expressed in Human Cells - ABIN2007893
Sussman, Sun, Krofft, Durvasula: SPARC accelerates disease progression in experimental crescentic glomerulonephritis. in The American journal of pathology 2009
these data identify a contributory role for DNA methylation (show HELLS Proteins) in regulating sparc expression in zebrafish embryogenesis.
Results establish a role for an ECM (show MMRN1 Proteins) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
Sparc is directly required for normal otolith growth
SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.
SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.
Tumor-produced SPARC and VCAM1 (show VCAM1 Proteins) are regulators of cancer extravasation.
The results of this study indicated that the loss of p53 (show TP53 Proteins) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.
This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function.
SPARC has a significant role in the development of concanavalin A -induced severe liver injury.
SPARC acts as an important mediator of age-related cardiac inflammation by increasing the expression of macrophage M1 markers and decreasing M2 markers.
SPARC inhibits growth factor-induced signaling in both INS-1 beta cells and primary mouse islets, and inhibits IGF-1-induced proliferation of INS-1 beta cells.
Age and SPARC change the extracellular matrix composition of the left ventricle.
findings suggest that SPARC plays a crucial role in the regulation of early B lymphopoiesis.
We identified five new biomarkers: GDF15 (show GDF15 Proteins), osteonectin, TRAP5, TWEAK (show TNFSF12 Proteins), and YKL40 (show CHI3L1 Proteins) as being promising markers for monitoring bone metastases.
CD90 (show THY1 Proteins) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.
SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]
tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.
SPARC is associated with carcinogenesis of oral squamous epithelium.
Studies indicate that SPARC (secreted protein acidic and rich in cysteine) gene is involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC).
MLKL upregulation in SPARC overexpressed cells treated with Ara (show FOXC1 Proteins)-C, indicates necrosis as a possible cell death process for the SKM-1 cells under these stringent conditions.
up-regulation of SPARC by oxLDL is independent of Runx2 (show RUNX2 Proteins), and it may be mediated by other transcription factors
findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA Proteins)), fibroblast growth factor 2 (FGF2 (show FGF2 Proteins)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
, basement-membrane protein 40
, secreted protein acidic and rich in cysteine
, cysteine-rich protein
, Secreted acidic cystein-rich glycoprotein (osteonectin)
, secreted acidic cysteine rich glycoprotein