You are viewing an incomplete version of our website. Please click to reload the website as full version.

Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) Proteins (SPARC)

SPARC encodes a cysteine-rich acidic matrix-associated protein. Additionally we are shipping SPARC Antibodies (212) and SPARC Kits (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPARC 20692 P07214
SPARC 6678 P09486
SPARC 24791 P16975
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top SPARC Proteins at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) (AA 18-303), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 100 μg Log in to see 5 to 7 Days
$317.63
Details
HOST_CHO Cells Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$325.50
Details
HOST_Escherichia coli (E. coli) Cow His tag 50 μg Log in to see 11 to 13 Days
$440.00
Details
HOST_Escherichia coli (E. coli) Wild boar His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$742.50
Details
HOST_Escherichia coli (E. coli) Rabbit His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details

SPARC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , ,
, ,
Rat (Rattus) ,

Top referenced SPARC Proteins

  1. Human SPARC Protein expressed in Escherichia coli (E. coli) - ABIN1047668 : Lankat-Buttgereit, Mann, Deutzmann, Timpl, Krieg: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). in FEBS letters 1988 (PubMed)

  2. Mouse (Murine) SPARC Protein expressed in Human Cells - ABIN2007893 : Sussman, Sun, Krofft, Durvasula: SPARC accelerates disease progression in experimental crescentic glomerulonephritis. in The American journal of pathology 2009 (PubMed)

More Proteins for Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) Interaction Partners

Zebrafish Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. these data identify a contributory role for DNA methylation (show HELLS Proteins) in regulating sparc expression in zebrafish embryogenesis.

  2. Results establish a role for an ECM (show MMRN1 Proteins) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.

  3. Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.

  4. Sparc is directly required for normal otolith growth

Mouse (Murine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  2. SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.

  3. Tumor-produced SPARC and VCAM1 (show VCAM1 Proteins) are regulators of cancer extravasation.

  4. The results of this study indicated that the loss of p53 (show TP53 Proteins) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.

  5. This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function.

  6. SPARC has a significant role in the development of concanavalin A -induced severe liver injury.

  7. SPARC acts as an important mediator of age-related cardiac inflammation by increasing the expression of macrophage M1 markers and decreasing M2 markers.

  8. SPARC inhibits growth factor-induced signaling in both INS-1 beta cells and primary mouse islets, and inhibits IGF-1-induced proliferation of INS-1 beta cells.

  9. Age and SPARC change the extracellular matrix composition of the left ventricle.

  10. findings suggest that SPARC plays a crucial role in the regulation of early B lymphopoiesis.

Human Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test

  2. We identified five new biomarkers: GDF15 (show GDF15 Proteins), osteonectin, TRAP5, TWEAK (show TNFSF12 Proteins), and YKL40 (show CHI3L1 Proteins) as being promising markers for monitoring bone metastases.

  3. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  4. CD90 (show THY1 Proteins) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.

  5. SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]

  6. tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.

  7. SPARC is associated with carcinogenesis of oral squamous epithelium.

  8. Studies indicate that SPARC (secreted protein acidic and rich in cysteine) gene is involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC).

  9. MLKL upregulation in SPARC overexpressed cells treated with Ara (show FOXC1 Proteins)-C, indicates necrosis as a possible cell death process for the SKM-1 cells under these stringent conditions.

  10. up-regulation of SPARC by oxLDL is independent of Runx2 (show RUNX2 Proteins), and it may be mediated by other transcription factors

Cow (Bovine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition

  2. This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA Proteins)), fibroblast growth factor 2 (FGF2 (show FGF2 Proteins)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.

Horse (Equine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue

SPARC Protein Profile

Protein Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.

Gene names and symbols associated with SPARC

  • secreted acidic cysteine rich glycoprotein (sparc)
  • secreted acidic cysteine rich glycoprotein (Sparc)
  • secreted protein, acidic, cysteine-rich (osteonectin) (SPARC)
  • secreted protein, acidic, cysteine-rich (osteonectin) (Sparc)
  • SPARC protein (MGC64258)
  • SPARC-like (LOC100855736)
  • AA517111 protein
  • BM-40 protein
  • hm:zeh0062 protein
  • ON protein
  • SPARC protein

Protein level used designations for SPARC

SPARC , osn , osteonectin , ON , basement-membrane protein 40 , secreted protein acidic and rich in cysteine , BM-40 , cysteine-rich protein , Secreted acidic cystein-rich glycoprotein (osteonectin) , secreted acidic cysteine rich glycoprotein

GENE ID SPECIES
321357 Danio rerio
20692 Mus musculus
6678 Homo sapiens
282077 Bos taurus
24791 Rattus norvegicus
595124 Sus scrofa
100009355 Oryctolagus cuniculus
386571 Gallus gallus
100860800 Capra hircus
595143 Canis lupus familiaris
100060119 Equus caballus
100174069 Pongo abelii
379441 Xenopus laevis
100855736 Canis lupus familiaris
Selected quality suppliers for SPARC Proteins (SPARC)
Did you look for something else?