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SPARC encodes a cysteine-rich acidic matrix-associated protein. Additionally we are shipping SPARC Kits (57) and SPARC Proteins (43) and many more products for this protein.
Showing 10 out of 229 products:
Mouse (Murine) Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899335
Arnold, Rivera, Carbon, Toombs, Chang, Bradshaw, Brekken: Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGF? activation. in PLoS ONE 2012
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Human Polyclonal SPARC Primary Antibody for EIA, IHC (fro) - ABIN265179
Schäkel, Mayer, Federle, Schmitz, Riethmüller, Rieber: A novel dendritic cell population in human blood: one-step immunomagnetic isolation by a specific mAb (M-DC8) and in vitro priming of cytotoxic T lymphocytes. in European journal of immunology 1999
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Human Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899340
Aguilera, Rivera, Hur, Carbon, Toombs, Goldstein, Dellinger, Castrillon, Brekken: Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. in Cancer research 2014
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Mouse (Murine) Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899334
Weaver, Sage, Yan: Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. in Journal of cellular biochemistry 2006
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Human Polyclonal SPARC Primary Antibody for IF (p), IHC (p) - ABIN738141
Chen, Wang, Xi, Xue, He, Zhang, Zhao: SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. in PLoS ONE 2012
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Human Monoclonal SPARC Primary Antibody for WB - ABIN1882278
Bradshaw, Graves, Motamed, Sage: SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Polyclonal SPARC Primary Antibody for IHC, IHC (fro) - ABIN4355498
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
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Human Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899338
Moreno, Ball, Andrade, McDermid, Stanimirovic: Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. in Glia 2006
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Human Polyclonal SPARC Primary Antibody for EIA, WB - ABIN453390
Said, Frierson, Chernauskas, Conaway, Motamed, Theodorescu: The role of SPARC in the TRAMP model of prostate carcinogenesis and progression. in Oncogene 2009
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these data identify a contributory role for DNA methylation (show HELLS Antibodies) in regulating sparc expression in zebrafish embryogenesis.
Results establish a role for an ECM (show MMRN1 Antibodies) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
Sparc is directly required for normal otolith growth
resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.
SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (show STS Antibodies) migration.
SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.
SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.
Tumor-produced SPARC and VCAM1 (show VCAM1 Antibodies) are regulators of cancer extravasation.
The results of this study indicated that the loss of p53 (show TP53 Antibodies) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.
This work suggests that SPARC could affect anxiety-related behavior by modulating neuronal activity, and that depression-related behavior is dependent upon the adult expression of SPARC, which affects adult brain function.
SPARC has a significant role in the development of concanavalin A -induced severe liver injury.
SPARC acts as an important mediator of age-related cardiac inflammation by increasing the expression of macrophage M1 markers and decreasing M2 markers.
SPARC inhibits growth factor-induced signaling in both INS-1 beta cells and primary mouse islets, and inhibits IGF-1-induced proliferation of INS-1 beta cells.
that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors
WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action
high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test
We identified five new biomarkers: GDF15 (show GDF15 Antibodies), osteonectin, TRAP5, TWEAK (show TNFSF12 Antibodies), and YKL40 (show CHI3L1 Antibodies) as being promising markers for monitoring bone metastases.
CD90 (show THY1 Antibodies) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.
SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]
tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.
SPARC is associated with carcinogenesis of oral squamous epithelium.
Studies indicate that SPARC (secreted protein acidic and rich in cysteine) gene is involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC).
findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA Antibodies)), fibroblast growth factor 2 (FGF2 (show FGF2 Antibodies)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
, basement-membrane protein 40
, secreted protein acidic and rich in cysteine
, cysteine-rich protein
, Secreted acidic cystein-rich glycoprotein (osteonectin)
, secreted acidic cysteine rich glycoprotein