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The protein encoded by SCTR is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. Additionally we are shipping Secretin Receptor Antibodies (61) and Secretin Receptor Kits (20) and many more products for this protein.
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Cysteine trapping identified charge-charge interactions between secretin (show SECR Proteins) and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.
Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.
High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors.
Results suggest that Secretin (show SECR Proteins) is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling.
Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1 (show PSG1 Proteins)-mediated transactivation.
Data suggest that the interaction between secretin (show SECR Proteins) peptide residue H1 and secretin receptor residue W274 is most compatible with a hydrophobic interaction.
binding and activity of a series of 11 truncated and lactam-constrained secretin (show SECR Proteins)(5-27) analogues at the prototypic member of this family, the secretin receptor
results demonstrate that secretin (show SECR Proteins) and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma
Increasing expression of secretin receptor competes for receptor modifying protein 3 (show HSPB3 Proteins) (RAMP3 (show RAMP3 Proteins)) association with calcitonin receptor-like receptor (CLR (show CALCRL Proteins)) to yield a functional adrenomedullin receptor (show GPR182 Proteins).
Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum.
In vivo, osmotic stress up-regulates the SCTR gene in the kidney cortex and medulla of wild-type mice, but does not do so in NFAT5 (show NFAT5 Proteins)(+/-) mice.
Animal studies demonstrate that secretin receptor (show GPR56 Proteins) deficiency slightly, but significantly, prolongs incubation time in female but not male mice.
Despite similar food intake, SCTR(-/-) mice have less weight, less fat, less hyperleptinemia and better glucose/insulin (show INS Proteins) tolerance on a high-fat diet, and less intestinal fatty acid absorption but similar energy expenditure and locomotor activity.
Immunohistochemical staining of the arcuate nucleus shows colocalization of Sctr with proopiomelanocortin (show POMC Proteins) that provide proof of signals downstream to the paraventricular nucleus that lead to food intake reduction.
Secretin (show SECR Proteins)-deficient mice exhibit decreased numbers of new neurons and increased apoptosis of progenitor cells in the dentate gyrus.
Findings identify SCT (show SECR Proteins) and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body.
data indicate that secretin (show SECR Proteins) exerts a direct action on pancreatic secretion through specific SEC-R coupled to the adenylate cyclase system
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism.
pancreatic secretin receptor