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The protein encoded by SCG3 is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Additionally we are shipping Secretogranin III Kits (11) and Secretogranin III Proteins (8) and many more products for this protein.
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HBXIP (show HBXIP Antibodies) facilitates the proliferation of hepatoma cells by up-regulating SCG3 via E2F1 (show E2F1 Antibodies) and miR (show MLXIP Antibodies)-509-3p modulation.
SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
SCG3 may be involved in apoptosis signal transduction as a caspase (show CASP3 Antibodies) substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release.
Our data suggest that genetic variations in the FTO (show FTO Antibodies), SCG3 and MTMR9 (show MTMR9 Antibodies) genes independently influence the risk of metabolic syndrome.
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs (show FBN1 Antibodies)) II and III.
SgIII was expressed in 41 of 47 neuroendocrine tumours. The expression of SgIII agreed well with that of CgA (show CGA Antibodies), CgB (show CGB Antibodies) and SgII (show SEMG2 Antibodies), with exceptions of phaeochromocytomas and parathyroid adenomas.
Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
these data suggest that SgIII, DMT-1 (show DMRT1 Antibodies) and HNP-1 (show DEFA1 Antibodies) are implicated in cell-mediated LDL oxidation.
we show by RNA silencing that CPE (show CPE Antibodies) and SgIII play a synergistic role in the trafficking of POMC (show POMC Antibodies) to granules of the regulated secretory pathway in AtT20 cells
SgIII knockdown impairs intracellular retention of chromogranin A (show CHGA Antibodies) and proopiomelanocortin (show POMC Antibodies) in AtT-20 cells.
The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits.
SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A (show CHGA Antibodies) to secretory granules in pituitary and pancreatic endocrine cells
SgIII and CPE (show CPE Antibodies) form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC (show POMC Antibodies)-derived peptides are transferred from CPE (show CPE Antibodies) to SgIII, and subsequently to CgA (show CGA Antibodies).
SCG2 (show SCG2 Antibodies), as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones\; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.