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The protein encoded by SCG3 is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Additionally we are shipping Secretogranin III Antibodies (70) and Secretogranin III Proteins (9) and many more products for this protein.
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HBXIP (show HBXIP ELISA Kits) facilitates the proliferation of hepatoma cells by up-regulating SCG3 via E2F1 (show E2F1 ELISA Kits) and miR (show MLXIP ELISA Kits)-509-3p modulation.
SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
SCG3 may be involved in apoptosis signal transduction as a caspase (show CASP3 ELISA Kits) substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release.
Our data suggest that genetic variations in the FTO (show FTO ELISA Kits), SCG3 and MTMR9 (show MTMR9 ELISA Kits) genes independently influence the risk of metabolic syndrome.
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs (show FBN1 ELISA Kits)) II and III.
SgIII was expressed in 41 of 47 neuroendocrine tumours. The expression of SgIII agreed well with that of CgA (show CGA ELISA Kits), CgB (show CGB ELISA Kits) and SgII (show SEMG2 ELISA Kits), with exceptions of phaeochromocytomas and parathyroid adenomas.
Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
these data suggest that SgIII, DMT-1 (show DMRT1 ELISA Kits) and HNP-1 (show DEFA1 ELISA Kits) are implicated in cell-mediated LDL oxidation.
we show by RNA silencing that CPE (show CPE ELISA Kits) and SgIII play a synergistic role in the trafficking of POMC (show POMC ELISA Kits) to granules of the regulated secretory pathway in AtT20 cells
SgIII knockdown impairs intracellular retention of chromogranin A (show CHGA ELISA Kits) and proopiomelanocortin (show POMC ELISA Kits) in AtT-20 cells.
The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits.
SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A (show CHGA ELISA Kits) to secretory granules in pituitary and pancreatic endocrine cells
SgIII and CPE (show CPE ELISA Kits) form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC (show POMC ELISA Kits)-derived peptides are transferred from CPE (show CPE ELISA Kits) to SgIII, and subsequently to CgA (show CGA ELISA Kits).
SCG2 (show SCG2 ELISA Kits), as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones\; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.