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mouse homolog plays a role in the transport and activation of proprotein convertase-2 (PC2)\; may regulate hormone secretion [RGD, Feb 2006].. Additionally we are shipping Secretogranin V (7B2 Protein) Antibodies (32) and Secretogranin V (7B2 Protein) Kits (17) and many more products for this protein.
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Dynamic modulation of prohormone convertase 2 (PC2 (show PCSK2 Proteins))-mediated precursor processing by 7B2 protein has a preferential effect on glucagon (show GCG Proteins) synthesis
7B2-related peptides modulate regulated secretion of ACTH (show POMC Proteins) in neuroendocrine cells.
7B2 nulls exhibit a multisystem disorder of vital organs, most notably the liver, in which massive steatosis and necrosis are observed. Metabolic derangements in glucose metabolism result in glycogen (show GYS1 Proteins) and fat deposition in liver
7B2 has a role in endoproteolytic processing in mouse brain
data indicate that null prohormone convertase 2 (show PCSK2 Proteins) and 7B2 protein are not phenotypically equivalent in pituitary proopiomelanocortin (POMC (show POMC Proteins)) biosynthesis and granule content
Phenotypic differences between the 7B2 and PC2 (show CBX4 Proteins) nulls and play a life-or-death role in the ACTH (show POMC Proteins) hypersecretion syndrome present in both 129 nulls.
phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP (show HSPA5 Proteins), which impairs its ability to bind substrate
Differential expression of 7B2 may contribute to the difference between B6 and C3H mice not only in glucagon (show GCG Proteins) production and secretion but also in glucose tolerance.
a role for Scg5 in the modulation of body weight
7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 (show CBX4 Proteins) forms from losing catalytic competence and then aggregating.
Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 (show GREM1 Proteins) duplication.
FAM20C (show FAM20C Proteins) plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing.
7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP
conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers
data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease
the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas.
SGNE1 was overexpressed in gastrointestinal peptide (show SPINK4 Proteins)-independent ACTH (show POMC Proteins)-independent macronodular adrenal hyperplasia. hyperplasia
SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development.
SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin (show INS Proteins) resistance, especially in the background of severe and early onset obesity
mouse homolog plays a role in the transport and activation of proprotein convertase-2 (PC2)\; may regulate hormone secretion
neuroendocrine protein 7B2
, secretogranin V
, secretory granule endocrine protein I
, secretory granule neuroendocrine protein 1, 7B2 protein
, Secretory granule neuroendocrine, protein 1 (7B2 protein)
, secretory granule neuroendocrine protein 1
, pituitary polypeptide
, prohormone convertase chaperone
, secretory granule, neuroendocrine protein 1 (7B2 protein)
, neuronal endocrine protein