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Secretory Leukocyte Peptidase Inhibitor Proteins (SLPI)

SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. Additionally we are shipping SLPI Antibodies (111) and SLPI Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLPI 6590 P03973
SLPI 20568 P97430
Rat SLPI SLPI 84386  
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Top SLPI Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Please inquire GST tag Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$206.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,S tag 100 μg Log in to see 11 to 13 Days
$880.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,196.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details

SLPI Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)
,

Top referenced SLPI Proteins

  1. SLPI Protein expressed in Escherichia coli (E. coli) - ABIN1046564 : Stetler, Brewer, Thompson: Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. in Nucleic acids research 1986 (PubMed)
    Show all 2 references for ABIN1046564

  2. Human SLPI Protein expressed in Escherichia coli (E. coli) - ABIN666651 : King, Wheelhouse, Cameron, McDonald, Lee, Entrican, Critchley, Horne: Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. in Human reproduction (Oxford, England) 2009 (PubMed)
    Show all 2 references for ABIN666651

  3. Human SLPI Protein expressed in Wheat germ - ABIN1320577 : Nikolakopoulou, Dutta, Chen, Miller, Trapp: Activated microglia enhance neurogenesis via trypsinogen secretion. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

More Proteins for Secretory Leukocyte Peptidase Inhibitor (SLPI) Interaction Partners

Human Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.

  2. Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2 (show ANXA2 Proteins).

  3. SLPI is an independent predictor for both OS and DSS (show NR0B1 Proteins) and a relevant prognostic biomarker in OSCC.

  4. The elevations in cervical elafin (show PI3 Proteins) and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.

  5. These results demonstrate that SLPI down-regulates pIgR (show PIGR Proteins) expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway by inhibiting degradation of IkappaBbeta (show NFKBIB Proteins) protein.

  6. Abnormal over-expression of SLPI in pancreatic cancer cells may be associated with the development of disease through its roles in promoting cancer cell survival and proliferation as well as anti-apoptosis.

  7. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (show IFNG Proteins)/SLPI axis that affects lung function.

  8. findings support a controlling role for SLPI in NET generation, which is of potential relevance to infectious and autoinflammatory diseases

  9. We identify SLPI as a new player in acquisition of microbial hyporesponsiveness by buccal and intestinal epithelium in the first weeks after microbial colonisation.

  10. Studies suggest that secretory leukocyte protease inhibitor (SLPI) as a mediator of systemic immune paresis in acute liver failure (ALF (show GTF2A1L Proteins)).

Mouse (Murine) Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 Proteins)-mediated control of SLPI and syndecan 4 (show SDC4 Proteins).

  2. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (show IFNG Proteins)/SLPI axis that affects lung function.

  3. Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.

  4. Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (show S100A8 Proteins), and lactotransferrin (show LTF Proteins), was reduced due to myeloid differentiation dactor 88 (MyD88 (show MYD88 Proteins)) deficiency.

  5. a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1

  6. These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.

  7. In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity

  8. The results underscore the importance of SLPI as a modulator of specific immunity that can also function at peripheral sites under pathogenic pressure.

  9. SLPI has a role in wound healing and innate immunity

  10. Results suggest that secretory leukoprotease inhibitor (SLPI) attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity.

SLPI Protein Profile

Protein Summary

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.

Gene names and symbols associated with SLPI

  • secretory leukocyte peptidase inhibitor (SLPI)
  • antileukoproteinase-like (LOC512548)
  • secretory leukocyte peptidase inhibitor (Slpi)
  • ALK1 protein
  • ALP protein
  • BLPI protein
  • ckpi protein
  • HUSI protein
  • HUSI-I protein
  • MATN4 protein
  • MPI protein
  • SLPI protein
  • WAP4 protein
  • WFDC4 protein

Protein level used designations for SLPI

antileukoproteinase , matrilin 4 , secretory leukocyte peptidase inhibitor , HUSI-1 , WAP four-disulfide core domain protein 4 , mucus proteinase inhibitor , protease inhibitor WAP4 , secretory leukocyte protease inhibitor (antileukoproteinase) , seminal proteinase inhibitor , ALP , secretory leukocyte protease inhibitor

GENE ID SPECIES
504598 Bos taurus
711156 Macaca mulatta
740668 Pan troglodytes
100137514 Papio anubis
100137521 Pongo abelii
512548 Bos taurus
6590 Homo sapiens
20568 Mus musculus
84386 Rattus norvegicus
100722975 Cavia porcellus
396886 Sus scrofa
641306 Ovis aries
100127207 Canis lupus familiaris
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