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SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. Additionally we are shipping SLPI Antibodies (111) and SLPI Kits (37) and many more products for this protein.
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SLPI Protein expressed in Escherichia coli (E. coli) - ABIN1046564
Stetler, Brewer, Thompson: Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. in Nucleic acids research 1986
Show all 2 references for ABIN1046564
Human SLPI Protein expressed in Escherichia coli (E. coli) - ABIN666651
King, Wheelhouse, Cameron, McDonald, Lee, Entrican, Critchley, Horne: Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. in Human reproduction (Oxford, England) 2009
Show all 2 references for ABIN666651
Human SLPI Protein expressed in Wheat germ - ABIN1320577
Nikolakopoulou, Dutta, Chen, Miller, Trapp: Activated microglia enhance neurogenesis via trypsinogen secretion. in Proceedings of the National Academy of Sciences of the United States of America 2013
The results indicate that SERPINE2 (show SERPINE2 Proteins) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.
Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2 (show ANXA2 Proteins).
SLPI is an independent predictor for both OS and DSS (show NR0B1 Proteins) and a relevant prognostic biomarker in OSCC.
The elevations in cervical elafin (show PI3 Proteins) and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.
These results demonstrate that SLPI down-regulates pIgR (show PIGR Proteins) expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway by inhibiting degradation of IkappaBbeta (show NFKBIB Proteins) protein.
Abnormal over-expression of SLPI in pancreatic cancer cells may be associated with the development of disease through its roles in promoting cancer cell survival and proliferation as well as anti-apoptosis.
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (show IFNG Proteins)/SLPI axis that affects lung function.
findings support a controlling role for SLPI in NET generation, which is of potential relevance to infectious and autoinflammatory diseases
We identify SLPI as a new player in acquisition of microbial hyporesponsiveness by buccal and intestinal epithelium in the first weeks after microbial colonisation.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 Proteins)-mediated control of SLPI and syndecan 4 (show SDC4 Proteins).
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (show S100A8 Proteins), and lactotransferrin (show LTF Proteins), was reduced due to myeloid differentiation dactor 88 (MyD88 (show MYD88 Proteins)) deficiency.
a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1
These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.
In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity
The results underscore the importance of SLPI as a modulator of specific immunity that can also function at peripheral sites under pathogenic pressure.
SLPI has a role in wound healing and innate immunity
Results suggest that secretory leukoprotease inhibitor (SLPI) attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity.
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.
, matrilin 4
, secretory leukocyte peptidase inhibitor
, WAP four-disulfide core domain protein 4
, mucus proteinase inhibitor
, protease inhibitor WAP4
, secretory leukocyte protease inhibitor (antileukoproteinase)
, seminal proteinase inhibitor
, secretory leukocyte protease inhibitor