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Sel-1 Suppressor of Lin-12-Like (C. Elegans) Proteins (SEL1L)

The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Additionally we are shipping SEL1L Antibodies (70) and SEL1L Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SEL1L 6400 Q9UBV2
SEL1L 20338 Q9Z2G6
Rat SEL1L SEL1L 314352 Q80Z70
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Top SEL1L Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

SEL1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) Interaction Partners

Human Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. The SEL1L critically regulates HRD1 (show SYVN1 Proteins)-mediated disposal of misfolded cargo through its short membrane spanning stretch.

  2. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients

  3. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.

  4. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (show INS Proteins) signalling to create a favourable micro-environment for ss-cell development and function.

  5. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.

  6. ATF6 (show ATF6 Proteins) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.

  7. ERdj5 (show DNAJC10 Proteins), by binding to Sel1L, triggers BiP (show GDF10 Proteins)-Cholera toxin interaction proximal to the Hrd1 (show SYVN1 Proteins) complex; postulate this scenario enables the Hrd1 (show SYVN1 Proteins)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (show GDF10 Proteins)

  8. SEL1L expression is a potential colorectal cancer (CRC (show CALR Proteins)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (show CALR Proteins) cancers

  9. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.

  10. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.

Mouse (Murine) Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. Sel1L-Hrd1 (show SYVN1 Proteins) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.

  2. Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (show SYVN1 Proteins) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  3. Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (show LPL Proteins) dimers from aggregation in the endoplasmic reticulum.

  4. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (show INS Proteins) signalling to create a favourable micro-environment for ss-cell development and function.

  5. Sel1L is an indispensable component of the mammalian Hrd1 (show SYVN1 Proteins) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.

  6. a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth

  7. an essential role for SEL1L in protein quality control during mouse embryonic development.

  8. Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development.

SEL1L Protein Profile

Protein Summary

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SEL1L

  • Sel1-like (Nham_0248)
  • Sel1-like (Nham_0743)
  • Sel1-like (Nham_1053)
  • Sel1-like (Nham_1754)
  • hypothetical LOC281082 (LOC281082)
  • sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)
  • sel-1 suppressor of lin-12-like (sel1l)
  • sel-1 suppressor of lin-12-like (C. elegans) (Sel1l)
  • AW493766 protein
  • MGC99195 protein
  • mKIAA4137 protein
  • PRO1063 protein
  • Sel-1L protein
  • SEL1-LIKE protein
  • Sel1h protein
  • SEL1L protein
  • SEL1L1 protein

Protein level used designations for SEL1L

Sel1-like , hypothetical LOC281082 , sel-1 suppressor of lin-12-like (C. elegans) , sel-1 suppressor of lin-12-like , protein sel-1 homolog 1-like , Suppressor of lin 12 (sel-1), C. elegans, homolog of , protein sel-1 homolog 1 , sel-1 suppressor of lin-12-like 1 , suppressor of lin-12-like protein 1 , Sel1 (suppressor of lin-12) 1 homolog , sel-1L , Suppressor of lin-12-like protein 1

GENE ID SPECIES
4030996 Nitrobacter hamburgensis X14
4031503 Nitrobacter hamburgensis X14
4031659 Nitrobacter hamburgensis X14
4032796 Nitrobacter hamburgensis X14
281082 Bos taurus
423391 Gallus gallus
453080 Pan troglodytes
708651 Macaca mulatta
735099 Xenopus laevis
100052711 Equus caballus
100231514 Taeniopygia guttata
100353303 Oryctolagus cuniculus
100377925 Saccoglossus kowalevskii
100380038 Xenopus (Silurana) tropicalis
100408799 Callithrix jacchus
100477463 Ailuropoda melanoleuca
100548852 Meleagris gallopavo
100583688 Nomascus leucogenys
6400 Homo sapiens
480409 Canis lupus familiaris
100155424 Sus scrofa
614959 Bos taurus
20338 Mus musculus
314352 Rattus norvegicus
101834260 Mesocricetus auratus
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