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SELP encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Additionally we are shipping SELP Kits (119) and SELP Proteins (35) and many more products for this protein.
Showing 10 out of 337 products:
Human Monoclonal SELP Primary Antibody for FACS - ABIN1106511
Bevilacqua, Nelson: Selectins. in The Journal of clinical investigation 1993
Show all 13 references for ABIN1106511
Human Monoclonal SELP Primary Antibody for FACS, IHC (fro) - ABIN118767
Sopper, Stahl-Hennig, Demuth, Johnston, Dörries, ter Meulen: Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys. in Cytometry 1998
Show all 13 references for ABIN118767
Cat (Feline) Monoclonal SELP Primary Antibody for FACS, ICC - ABIN259995
Johnson, Wearden, Kocyildirim, Maul, Woolley, Ye, Strickler, Borovetz, Wagner: Platelet activation in ovines undergoing sham surgery or implant of the second generation PediaFlow pediatric ventricular assist device. in Artificial organs 2011
Show all 8 references for ABIN259995
Goat Monoclonal SELP Primary Antibody for FACS - ABIN120299
Massaguer, Engel, Pérez-del-Pulgar, Bosch, Pizcueta: Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P). in Tissue antigens 2001
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Human Polyclonal SELP Primary Antibody for IHC, WB - ABIN223314
He, Horuk, Moochhala, Bhatia: Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. in American journal of physiology. Gastrointestinal and liver physiology 2007
Show all 4 references for ABIN223314
Human Polyclonal SELP Primary Antibody for FACS, IF (p) - ABIN670131
Ma, Niu, Sun, Wang, Luo, Zhang, Wang: Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta. in Archives of toxicology 2012
Show all 3 references for ABIN670131
Human Monoclonal SELP Primary Antibody for FACS - ABIN4897925
Ramachandran, Morice, Compton: Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts. in American journal of respiratory cell and molecular biology 2006
Show all 2 references for ABIN4897925
Cow (Bovine) Monoclonal SELP Primary Antibody for FACS - ABIN181983
Massaguer, Engel, Tovar, March, Rigol, Solanes, Bosch, Pizcueta: Characterization of platelet and soluble-porcine P-selectin (CD62P). in Veterinary immunology and immunopathology 2003
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Study concluded that the genotype and allele frequencies of SELP (show SEPP1 Antibodies) S290N were not significant different between the acute ischemic stroke case group and the control group as well as between each subtype group and the control group
High SELP (show SEPP1 Antibodies) expression is associated with Inflamed Atherosclerotic Plaque.
Circulating P-selectin levels were closely associated with endocan (show ESM1 Antibodies) levels in obese children and adolescents with non-alcoholic fatty liver disease.
Primary Aldosteronism is related to platelet activation, expressed as higher plasma values of soluble CD40L (show CD40LG Antibodies) and soluble P-selectin values.
Immobilized P-selectin-induced calcium signaling of HL-60 cells is P-selectin concentration- and mechanical force-dependent
results found that LMWF protected the renal function in diabetic nephropathy rats and alleviated inflammation through the modulation of P-selectin and inflammatory cytokines. LMWF may have therapeutic potential against diabetic nephropathy.
The study establishes that thrombotic-inflammatory pathways enhancing P-selectin exposure unrelated to treatment might be activated in patients, while the event rate remained lowered, and hence, treatment strategies should be inclusive to control these factors.
This study could not support the potential benefit of the high-dose vitamin D on plasma level of P-selectin and hs-CRP (show CRP Antibodies) in patients with VTE.
The level of d-dimer, P-selectin, and platelet count might be good candidate predictive markers for PVT in patients with cirrhotic PHT after devascularization. The combined test of the 3 markers can increase the value of prediction.
preliminary result indicated the beneficial effect of serine on the expression of SelP (show SEPP1 Antibodies) and GPx (show GPX1 Antibodies), which suggested that it might be a candidate for combined selenium supplement.
Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with recurrent airway obstruction may contribute to the formation of platelet aggregates in their respiratory system.
Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE (show SELE Antibodies) were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.
SELP mediates the attachment of peripheral blood leukocytes to endothelium and provides novel evidence that its high polymorphism is likely to affect biological function. This may potentially influence leukocyte migration and fertility, both key to successful performance in dairy cows.
deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (show TGFB1 Antibodies) content, and corrected the hematopoietic stem cells distribution that in Gata1 (show GATA1 Antibodies)(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.
The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury.
Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis.
Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp (show SEPP1 Antibodies) and human SELP (show SEPP1 Antibodies) genes.
P-selectin has a role in endothelial progenitor cells' inhibition of platelet function
Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis.
Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth.
P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases.
P-selectin is an important adhesion molecule (show NCAM1 Antibodies) vital for infiltration of regulatory T cells into mouse mammary tumors
Administering human recombinant PTX3 (show PITX3 Antibodies) to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice.
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
CD62 antigen-like family member P
, granule membrane protein 140
, leukocyte-endothelial cell adhesion molecule 3
, platelet activation dependent granule-external membrane protein
, selectin, platelet
, granulocyte membrane protein
, platelet alpha-granule membrane protein
, CD62P antigen
, cell adhesion molecule