Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) Proteins (SELP)

SELP encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Additionally we are shipping SELP Antibodies (353) and SELP Kits (118) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SELP 25651 P98106
SELP 6403 P16109
SELP 20344 Q01102
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Top SELP Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 20 to 21 Days
$272.80
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HOST_Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
HOST_Human Cells Rhesus Monkey His tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$352.00
Details
HOST_HEK-293 Cells Human His tag   100 μg Log in to see 2 to 3 Days
$515.63
Details

SELP Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) , ,
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Human , , , ,
, , , , ,
Mouse (Murine) , , ,
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Top referenced SELP Proteins

  1. Mouse (Murine) SELP Protein expressed in Human Cells - ABIN2008263 : Johnson-Tidey, McGregor, Taylor, Poston: Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. in The American journal of pathology 1994 (PubMed)

More Proteins for Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) Interaction Partners

Human Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

  1. Transgenic expression of SELP (show SEPP1 Proteins) is atherogenic in Apoe (show APOE Proteins)(-/-) mice, suggesting that P-selectin contributes to atherogenesis.

  2. These results provide a novel insight into the mechano-chemical regulation mechanism for P-selectin-induced calcium signaling of neutrophils in flow.

  3. Data indicate no association of maternal or fetal ITGA2 (show ITGA2 Proteins) C807T SNP, ITGB3 (show ITGB3 Proteins) T1565C SNP, PECAM1 (show PECAM1 Proteins) CTG - GTG (show GGT1 Proteins) and SELP (show SEPP1 Proteins) A/C polymorphisms with fetal growth restriction (FGR (show FGR Proteins)).

  4. Study concluded that the genotype and allele frequencies of SELP (show SEPP1 Proteins) S290N were not significant different between the acute ischemic stroke case group and the control group as well as between each subtype group and the control group

  5. High SELP (show SEPP1 Proteins) expression is associated with Inflamed Atherosclerotic Plaque.

  6. Circulating P-selectin levels were closely associated with endocan (show ESM1 Proteins) levels in obese children and adolescents with non-alcoholic fatty liver disease.

  7. Primary Aldosteronism is related to platelet activation, expressed as higher plasma values of soluble CD40L (show CD40LG Proteins) and soluble P-selectin values.

  8. Immobilized P-selectin-induced calcium signaling of HL-60 cells is P-selectin concentration- and mechanical force-dependent

  9. results found that LMWF protected the renal function in diabetic nephropathy rats and alleviated inflammation through the modulation of P-selectin and inflammatory cytokines. LMWF may have therapeutic potential against diabetic nephropathy.

  10. The study establishes that thrombotic-inflammatory pathways enhancing P-selectin exposure unrelated to treatment might be activated in patients, while the event rate remained lowered, and hence, treatment strategies should be inclusive to control these factors.

Horse (Equine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

  1. Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with recurrent airway obstruction may contribute to the formation of platelet aggregates in their respiratory system.

Cow (Bovine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

  1. Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE (show SELE Proteins) were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.

  2. SELP mediates the attachment of peripheral blood leukocytes to endothelium and provides novel evidence that its high polymorphism is likely to affect biological function. This may potentially influence leukocyte migration and fertility, both key to successful performance in dairy cows.

Mouse (Murine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

  1. deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (show TGFB1 Proteins) content, and corrected the hematopoietic stem cells distribution that in Gata1 (show GATA1 Proteins)(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.

  2. The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury.

  3. Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis.

  4. Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp (show SEPP1 Proteins) and human SELP (show SEPP1 Proteins) genes.

  5. P-selectin has a role in endothelial progenitor cells' inhibition of platelet function

  6. Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis.

  7. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth.

  8. P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases.

  9. P-selectin is an important adhesion molecule (show NCAM1 Proteins) vital for infiltration of regulatory T cells into mouse mammary tumors

  10. Administering human recombinant PTX3 (show PITX3 Proteins) to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice.

SELP Protein Profile

Protein Summary

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Gene names and symbols associated with SELP

  • selectin P (Selp)
  • selectin P (granule membrane protein 140kDa, antigen CD62) (SELP)
  • selectin P (granule membrane protein 140kDa, antigen CD62) (Selp)
  • selectin, platelet (Selp)
  • CD62 protein
  • CD62P protein
  • GMP-140 protein
  • GMP140 protein
  • Grmp protein
  • LECAM3 protein
  • PADGEM protein
  • PSEL protein
  • PSELECT protein

Protein level used designations for SELP

CD62 antigen-like family member P , GMP-140 , LECAM3 , P-selectin , PADGEM , granule membrane protein 140 , leukocyte-endothelial cell adhesion molecule 3 , platelet activation dependent granule-external membrane protein , selectin, platelet , granulocyte membrane protein , platelet alpha-granule membrane protein , CD62P antigen , cell adhesion molecule

GENE ID SPECIES
25651 Rattus norvegicus
6403 Homo sapiens
100009695 Equus caballus
443305 Ovis aries
397150 Sus scrofa
100009534 Oryctolagus cuniculus
100716162 Cavia porcellus
281486 Bos taurus
403994 Canis lupus familiaris
424364 Gallus gallus
20344 Mus musculus
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