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Selenocysteine lyase (SCLY\; EC 220.127.116.11) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Selenocysteine Lyase Antibodies (37) and Selenocysteine Lyase Kits (4) and many more products for this protein.
Showing 10 out of 13 products:
Human SCLY Protein expressed in Baculovirus infected Insect Cells - ABIN2006364
Esaki, Nakamura, Tanaka, Soda: Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine. Mammalian distribution and purification and properties of pig liver enzyme. in The Journal of biological chemistry 1982
Upregulation of TAL1 (show TAL1 Proteins) is associated with T-cell acute lymphoblastic leukemia.
Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Proteins), FLI1 (show FLI1 Proteins) and TAL1 (show TAL1 Proteins), enables large-scale production of megakaryocytes from human pluripotent stem cells.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
a successful induction of gamma-globin (show HBG1 Proteins) includes a reduction in BCL11A (show BCL11A Proteins), KLF1 (show KLF1 Proteins) and TAL1 (show TAL1 Proteins) expression.
SCL (show KRT7 Proteins)-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.
These results indicate that KLF1 (show KLF1 Proteins) plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Proteins) and TAL1 (show TAL1 Proteins) occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping
Scl (show KRT7 Proteins) binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.
SCL/TAL1 (show TAL1 Proteins) is located in the up-stream of MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway and partially regulates hematopoiesis by modulating the phosphorylation level of the key proteins in MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway.
study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB (show MYB Proteins) transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 (show TAL1 Proteins) oncogene (show RAB1A Proteins); MYB (show MYB Proteins) binds to this new site
The results indicate that TAL1 plays a critical role in chromatin loop formation between the gamma-globin genes and locus control region, which is a critical step for the transcription of the gamma-globin genes.
This study showed that Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1 (show SEPP1 Proteins)(-/-) mice), selenoprotein P (Sepp1 (show SEPP1 Proteins)) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 (show GPX1 Proteins) by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly
These findings provide the first in vivo evidence that Scly and Sepp1 (show SEPP1 Proteins) work cooperatively to maintain selenoprotein function in the mammalian brain.
The results suggested a dependence of glucose and lipid homeostasis on selenocysteine lyase activity. These findings connect Se and energy metabolism and demonstrate for the first time a unique physiological role of selenocysteine lyase.
Scly knockout mice do not display neurological dysfunction comparable to Sepp1 (show SEPP1 Proteins) knockout mice.
Selenocysteine lyase (SCLY\; EC 18.104.22.168) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000
, Selenocysteine lyase
, selenocysteine lyase; Selenocysteine reductase
, selenocysteine reductase
, T-cell acute lymphocytic leukemia protein 1
, T-cell leukemia/lymphoma protein 5
, class A basic helix-loop-helix protein 17
, stem cell protein
, tal-1 product