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SEPHS1 encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Additionally we are shipping SEPHS1 Antibodies (34) and many more products for this protein.
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Data found that several malignant characteristics of SPS1-deficient F9 cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (show PDSS1 Proteins) (mSPS1 (show PDSS1 Proteins)) and hDLP1 (show PDSS2 Proteins) (mDLP1 (show PDSS1 Proteins))
Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS (show SLA Proteins), SECP43, SEPHS1, and SEPHS2 (show SEPHS2 Proteins)); SECP43, which interacts with SEPSECS (show SLA Proteins) and SEPHS1, is a globular protein that forms oligomers in vivo.
Three SNPs in SEPSECS (show SLA Proteins) and SEPHS1 were found to significantly interact with serum selenium level and Crohn's Disease.
Five alternative splice variants of human SPS1 (major type, DeltaE2, DeltaE8, +E9, +E9a) were identified wherein +E9 and +E9a make the same protein.
the Sps1 (show SRM Proteins)-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 (show SEPHS2 Proteins) enzyme can function with a selenite assimilation system
Sps1 (show SRM Proteins) affect cell viability upon ionizing radiation via modulation of p53 (show TP53 Proteins) activity. Sps1 (show SRM Proteins) and its product selenophosphate might be involved in cancer prevention in a p53 (show TP53 Proteins)-dependent manner and could be applied to development of a novel cancer therapy.
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.
selenide, water dikinase 1
, selenium donor protein 1
, selenophosphate synthase 1
, selenophosphate synthetase 1
, selenide, water dikinase 1-like
, selenophosphate synthetase 1 +E9
, selenophosphate synthetase 1 +E9a
, selenophosphate synthetase 1 delta E2
, selenophosphate synthetase 1 delta E8
, selenophosphate synthetase 1 major
, UDP-glucose-fructose-phosphate glucosyltransferase
, sucrose phosphate synthase
, sucrose-phosphate synthase