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anti-Selenoprotein N, 1 (SEPN1) Antibodies

SEPN1 encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Additionally we are shipping and SEPN1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SEPN1 57190 Q9NZV5
SEPN1 74777  
SEPN1 616379  
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Top anti-SEPN1 Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SEPN1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB SEPN1 Antibody (C-term) (ABIN656385) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human skeletal muscle tissue stained with SEPN1 antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of SEPN1 Antibody (C-term) Cat.-No AP53849PU-N in Hela cell line lysates (35ug/lane).This demonstrates the SEPN1 antibody detected the SEPN1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

SEPN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,


, , , , ,
Mouse (Murine) ,


Cow (Bovine)


Top referenced anti-SEPN1 Antibodies

  1. Human Polyclonal SEPN1 Primary Antibody for EIA, IHC (p) - ABIN954715 : Arbogast, Beuvin, Fraysse, Zhou, Muntoni, Ferreiro: Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment. in Annals of neurology 2009 (PubMed)
    Show all 3 references for ABIN954715

  2. Cow (Bovine) Polyclonal SEPN1 Primary Antibody for IHC, WB - ABIN2773903 : Okamoto, Takashima, Higuchi, Matsuyama, Suehara, Nishihira, Hashiguchi, Hirano, Ng, Nakagawa, Izumo, Osame, Arimura: Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by novel mutations of selenoprotein N gene. in Neurogenetics 2006 (PubMed)

  3. Human Polyclonal SEPN1 Primary Antibody for IHC (p), WB - ABIN656385 : Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007 (PubMed)

More Antibodies against SEPN1 Interaction Partners

Human Selenoprotein N, 1 (SEPN1) interaction partners

  1. The physiological function of SelN in muscle tissue and the pathogenesis leading to SEPN1-related myopathies. [Review]

  2. Data show that the spectrum of severity of SEPN1-related myopathiesis wider than previously reported.

  3. Data show that Argonaute 2 (show EIF2C2 Antibodies) expression is critical for stem cells to escape senescence by downregulating miR10b and miR23b, and that selenoprotein N1 is also involved in ATSC survival and self-renewal through ROS (show ROS1 Antibodies)-mediated p38 MAPK (show MAPK14 Antibodies) inactivation.

  4. this series of patients illustrates the clinical, histopathological and MRI (show C7ORF49 Antibodies) findings of SEPN1-related myopathy. It also adds new mutations to the limited number of fully described pathogenic SEPN1 variants.

  5. Mutations of the selenoprotein N gene, which is implicated in rigid spine muscular dystrophy, cause the classical phenotype of multiminicore disease

  6. A new SEPN1 point mutation, 943g->A causing G315S was found in a rigid spine muscular dystrophy patient with cor pulmonale.

  7. SEPN1 mutation analysis revealed that the patient was a compound heterozygote: a previously described insertion (713-714 insA (show INS Antibodies)), and a novel nonsense mutation (R439stop).

  8. Two patients with 'Dropped head syndrome' due to mutations in SEPN1 genes.

  9. SEPN1 is the second genetic cause of CFTD (show ACTA1 Antibodies) and the first cause of autosomal recessive CFTD (show ACTA1 Antibodies) to be identified to our knowledge. CFTD (show ACTA1 Antibodies) is the fourth clinicopathological presentation that can be associated with mutations in SEPN1.

  10. identification of this mutation affecting a conserved base in the selenocysteine insertion sequence functional motif thereby reveals the structural basis for a novel pathological mechanism leading to SEPN1-related myopathy

Mouse (Murine) Selenoprotein N, 1 (SEPN1) interaction partners

  1. SEPN1 enhances SERCA2 activity by reducing luminal cysteines that are hyperoxidized by ERO1-generated peroxides.

  2. SepN deficiency leads to abnormal lung development characterized by enlarged alveoli, which is associated with decreased tissue elastance and increased quasi-static compliance of Sepn1(-/-) lungs.

  3. Data show that Sepn1(-/-) mice developed an obvious phenotype, characterized by limited motility and body rigidity during the swimming session.

  4. we describe for the first time a major physiological function of SelN in skeletal muscles, as a key regulator of SC function, which likely plays a central role in the pathophysiological mechanism leading to SEPN1-RM.

  5. In whole embryos, Sepn1 transcripts were detected as early as E5.5, with expression levels peaking at E12.5, and then strongly decreasing until birth.

Zebrafish Selenoprotein N, 1 (SEPN1) interaction partners

  1. alteration of myofibril architecture and tendon-like structure in embryos deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy

  2. sepn1 and ryr1 (show RYR1 Antibodies) are required for the same cellular differentiation events and are needed for normal calcium fluxes

SEPN1 Antigen Profile

Protein Summary

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with SEPN1

  • selenoprotein N, 1 (SEPN1) antibody
  • selenoprotein N, 1 (Sepn1) antibody
  • selenoprotein N, 1 (sepn1) antibody
  • 1110019I12Rik antibody
  • AI414492 antibody
  • cb686 antibody
  • CFTD antibody
  • MDRS1 antibody
  • RSMD1 antibody
  • RSS antibody
  • SELN antibody
  • SePN antibody
  • wu:fb06g01 antibody
  • wu:fb73d02 antibody
  • wu:fv41b08 antibody
  • zgc:101091 antibody

Protein level used designations for SEPN1

selenoprotein N , selN

GENE ID SPECIES
57190 Homo sapiens
100037963 Sus scrofa
616379 Bos taurus
74777 Mus musculus
352914 Danio rerio
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