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Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additionally we are shipping SEMA3E Antibodies (89) and SEMA3E Kits (15) and many more products for this protein.
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Authors suggest that silencing of Sema3E contributes to the pathogenesis of gastric cancer.
Findings suggest that Plexin-D1 (show PLXND1 Proteins)/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc (show CYP11A1 Proteins)) endothelium.
Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F (show SEMA3F Proteins).
these results identify SEMA3E as an essential gene for GnRH (show GNRH1 Proteins) neuron development, uncover a neurotrophic function for SEMA3E in the developing brain
The ANGPTL4 may be a candidate target in DME treatment and a biomarker of ischemic-induced retinopathy, including diabetic retinopathy.
Semaphorin 3d (show SEMA3D Proteins) requires neuropilin 1 (show NRP1 Proteins) or PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins), whereas semaphorin 3e requires plexin D1 (show PLXND1 Proteins) in directing endothelial motility.
The identification and characterization of SH3BP1 (show SH3BP1 Proteins) as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior.
Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration.
A critical role of Sema3E/Plexin D1 (show PLXND1 Proteins) interaction in tumor resistance to apoptosis.
Loss of Sema3E expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer.
Our results demonstrate that sema3e/plexin D1 (show PLXND1 Proteins) modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues.
Sema3E is a natural negative regulator of the migration of PlexinD1-positive Cajal-Retzius (CR) cells originating in the cortical hem. Sema3E/PlexinD1 signaling controls the motogenic potential of CR cells in vitro and in vivo.
Our results indicate that Sema3e, secreted by damaged hepatocytes, affects sinusoidal regeneration in a paracrine manner during liver regeneration
Semaphorin 3d (show SEMA3D Proteins) requires neuropilin 1 (show NRP1 Proteins) or PI3K/Akt (show AKT1 Proteins), whereas semaphorin 3e requires plexin D1 (show PLXND1 Proteins) in directing endothelial motility.
Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools.
Sema3E acts as a chemoattractant for macrophages, with p53 (show TP53 Proteins)-induced upregulation of Sema3E expression provoking adipose tissue inflammation and systemic insulin (show INS Proteins) resistance in association with dietary obesity.
beta1 integrin adhesion is controlled by the plexinD1-sema3E axis in mice
Sema3E(-) (/) (-) mice survive throughout development and into adulthood, despite severe initial vascular defects.
Sema3E mRNA was highly downregulated in plaque macrophages
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.
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