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The semaphorins are a family of proteins that are involved in signaling. Additionally we are shipping Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F Kits (12) and Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F Proteins (6) and many more products for this protein.
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SEMA3F-NRP2 (show NELL2 Antibodies) interactions inhibit intracellular PI-3K activity, mTORC2 (show CRTC2 Antibodies)-dependent signaling, RhoA (show RHOA Antibodies) activity and cytoskeletal stress fiber formation.
Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2 (show NRP2 Antibodies)) are expressed in the thymus.
SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2 (show ASCL2 Antibodies)-CXCR4 (show CXCR4 Antibodies) signaling axis.
SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis.
Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E (show SEMA3E Antibodies) and SEMA3F.
Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for colorectal cancer
Data suggest that SEMA3F C-terminal domain exhibits high-affinity binding of neuropilin-1 (NRP1 (show NRP1 Antibodies); thus inhibiting binding of vascular endothelial growth factor A (show VEGFA Antibodies) to NRP1 (show NELL1 Antibodies)); this interaction may be involved in anti-angiogenic activity of SEMA3F.
A functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
This study demonstrated a marked loss of noradrenergic and sensory nerve fibers in polyp mucosa, which was associated with a strong increase of semaphorin 3F and 3A.
showed that transcription of SEMA3F is directly regulated by RORalpha
The authors demonstrate that expression of Semaphorin-3F in the outer hair cell region inhibits type I spiral ganglion neuron process extension by activating Neuropilin-2 (show NRP2 Antibodies) receptors expressed on spiral ganglion neurons.
the embryonically developed wiring deficits in Sema3F mutants persist until adulthood
Sema4A (show Sema4a Antibodies) promotes Th1 (show HAND1 Antibodies) and Th17 differentiation and increases adhesive activation of T cells to endothelial cells, even in the presence of IFN-beta (show IFNB1 Antibodies).
In a growth cone collapse assay, mouse embryonic stem cell-derived spinal motor neurons respond to ephrin-A5 (show EFNA5 Antibodies), semaphorin(Sema (show SEMA3B Antibodies))3f, and Sema3a (show SEMA3A Antibodies) in a concentration-dependent manner.
Sema3F is secreted by early-arriving axons of olfactory sensory neurons and is deposited at the anterodorsal olfactory bulb to repel Nrp2 (show NRP2 Antibodies)-positive axons that arrive later.
These data suggest that Sema3F plays a relatively restricted, if any, role in its receptor expression and postnatal development of the somatosensory cortex, the cerebellum, and the main olfactory system.
Sema3F is the principal ligand for Npn-2 (show NRP2 Antibodies)-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry
Sema3F alternatively spliced isoforms share common axonal chemorepulsive properties and binding to neuropilin (show NRP1 Antibodies) receptors, and are found to regulate endothelial cell morphology by remodeling lamellipodial protrusions.
Sema (show SEMA3B Antibodies) 3A and 3F, but not Sema (show SEMA3B Antibodies) 3C or 3E, induce chemorepulsion of septal axons.
Using sema3F-/- mice, we show that Sema3F is critical for vomeronasal sensory neuron axonal fasciculation and for segregation of these sensory afferents from the main olfactory system and lamina-specific targeting of olfactory sensory axons
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993
, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
, sema iv
, semaphorin 3F
, semaphorin IV
, sema III/F
, sema IV
, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3F
, semaphorin III/F