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anti-Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Antibodies

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Additionally we are shipping Sema4a Proteins (12) and Sema4a Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Sema4a 64218 Q9H3S1
Sema4a 20351 Q62178
Sema4a 310630  
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Top anti-Sema4a Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-SEMA4A Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SEMA4A Antibody (N-term) Cat.-No AP53846PU-N in Mouse kidney tissue lysates (35ug/lane). This demonstrates the SEMA4A antibody detected the SEMA4A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse FITC FACS 100 μL Log in to see 10 to 12 Days
$392.70
Details
Human Mouse Un-conjugated FACS, IP 0.1 mg Log in to see 6 to 8 Days
$346.50
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse PE FACS 100 μg Log in to see 10 to 12 Days
$260.89
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7/Jurkat cells, using SEMA4A Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using SEMA4A Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB SEMA4A Antibody (N-term)  western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the SEMA4A antibody detected the SEMA4A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry analysis of SEMA4A Antibody in paraffin-embedded human brain tissue. Western blot analysis of SEMA4A Antibody in extracts from COS-7 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

Sema4a Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sema4a Antibodies

  1. Human Polyclonal Sema4a Primary Antibody for EIA, WB - ABIN954721 : Schmidt-Kastner, Yamamoto, Hamasaki, Yamamoto, Parel, Schmitz, Dorey, Blanks, Preising: Hypoxia-regulated components of the U4/U6.U5 tri-small nuclear riboprotein complex: possible role in autosomal dominant retinitis pigmentosa. in Molecular vision 2008 (PubMed)
    Show all 5 references for ABIN954721

  2. Human Monoclonal Sema4a Primary Antibody for FACS - ABIN2662841 : Delgoffe, Woo, Turnis, Gravano, Guy, Overacre, Bettini, Vogel, Finkelstein, Bonnevier, Workman, Vignali: Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. in Nature 2013 (PubMed)
    Show all 4 references for ABIN2662841

  3. Human Polyclonal Sema4a Primary Antibody for IP, ELISA - ABIN1999255 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 4 references for ABIN1999255

  4. Human Monoclonal Sema4a Primary Antibody for FACS, IP - ABIN1449187 : Kikutani, Kumanogoh: Semaphorins in interactions between T cells and antigen-presenting cells. in Nature reviews. Immunology 2003 (PubMed)
    Show all 2 references for ABIN1449187

  5. Dog (Canine) Polyclonal Sema4a Primary Antibody for WB - ABIN2777831 : Püschel, Adams, Betz: Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. in Neuron 1995 (PubMed)

More Antibodies against Sema4a Interaction Partners

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. Sema4A activated the Akt (show AKT1 Antibodies) pathway via Plexin D1 (show PLXND1 Antibodies) receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  2. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  3. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

  4. PACAP (show ADCYAP1 Antibodies) released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function.

  5. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  6. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice.

  7. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP.

  8. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 (show TH1L Antibodies) cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing.

  9. Mutations within the SEMA4A gene cause various retinal degnerative diseases.

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. SEMA4A is required for optimal activation of mTORC1 in CD8 (show CD8A Antibodies)+ T cells.

  2. Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 (show NRP1 Antibodies) axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity

  3. Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development.

  4. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  5. A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans.

  6. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.

  7. Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries.

  8. Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness.

  9. experiments using knockout mice revealed that Sema4A but not Sema7A (show SEMA7A Antibodies) was required for the effect produced by Th1 (show HAND1 Antibodies) cells on neurite outgrowth from cortical neurons.

  10. Data indicated that Sema4A could function as a chemo-repulsive cue by activating a receptor whose signal is transmitted to Rho-kinase (show ROCK2 Antibodies) and induced growth cone collapse of hippocampal neurons.

Sema4a Antigen Profile

Protein Summary

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Sema4a

  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (SEMA4A) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a) antibody
  • AI132332 antibody
  • CORD10 antibody
  • RP35 antibody
  • SEMA4A antibody
  • Semab antibody
  • SemB antibody

Protein level used designations for Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPECIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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