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Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) ELISA Kits

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Additionally we are shipping Sema4a Antibodies (79) and Sema4a Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Sema4a 64218 Q9H3S1
Anti-Mouse Sema4a Sema4a 20351 Q62178
Anti-Rat Sema4a Sema4a 310630  
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Top Sema4a ELISA Kits at antibodies-online.com

Showing 1 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.131 ng/mL 31.25-2000 pg/mL 96 Tests Log in to see 9 to 11 Days
$810.53
Details

More ELISA Kits for Sema4a Interaction Partners

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. Sema4A activated the Akt (show AKT1 ELISA Kits) pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  2. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  3. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

  4. PACAP (show ADCYAP1 ELISA Kits) released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function.

  5. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  6. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice.

  7. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP.

  8. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 (show TH1L ELISA Kits) cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing.

  9. Mutations within the SEMA4A gene cause various retinal degnerative diseases.

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. SEMA4A is required for optimal activation of mTORC1 in CD8 (show CD8A ELISA Kits)+ T cells.

  2. Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 (show NRP1 ELISA Kits) axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity

  3. Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development.

  4. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  5. A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans.

  6. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.

  7. Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries.

  8. Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness.

  9. experiments using knockout mice revealed that Sema4A but not Sema7A (show SEMA7A ELISA Kits) was required for the effect produced by Th1 (show HAND1 ELISA Kits) cells on neurite outgrowth from cortical neurons.

  10. Data indicated that Sema4A could function as a chemo-repulsive cue by activating a receptor whose signal is transmitted to Rho-kinase (show ROCK2 ELISA Kits) and induced growth cone collapse of hippocampal neurons.

Sema4a Antigen Profile

Antigen Summary

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Sema4a

  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (SEMA4A) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a) antibody
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a) antibody
  • AI132332 antibody
  • CORD10 antibody
  • RP35 antibody
  • SEMA4A antibody
  • Semab antibody
  • SemB antibody

Protein level used designations for Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPECIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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