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Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A Proteins (Sema4a)

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Additionally we are shipping Sema4a Antibodies (79) and Sema4a Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Sema4a 64218 Q9H3S1
Sema4a 20351 Q62178
Rat Sema4a Sema4a 310630  
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Top Sema4a Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Human Mouse His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Sema4a Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) , ,
,

Top referenced Sema4a Proteins

  1. Human Sema4a Protein expressed in Human Cells - ABIN2004760 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 4 references for ABIN2004760

  2. Human Sema4a Protein expressed in HEK-293 Cells - ABIN2181737 : Abid, Ismail, Mehdi, Khaliq: Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases. in Journal of medical genetics 2006 (PubMed)

  3. Human Sema4a Protein expressed in Wheat germ - ABIN1319469 : Mogie, Shanks, Nkyimbeng-Takwi, Smith, Davila, Lipsky, DeTolla, Keegan, Chapoval: Neuroimmune semaphorin 4A as a drug and drug target for asthma. in International immunopharmacology 2013 (PubMed)

More Proteins for Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaction Partners

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. Sema4A activated the Akt (show AKT1 Proteins) pathway via Plexin D1 (show PLXND1 Proteins) receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  2. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  3. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

  4. PACAP (show ADCYAP1 Proteins) released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function.

  5. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  6. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice.

  7. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP.

  8. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 (show TH1L Proteins) cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing.

  9. Mutations within the SEMA4A gene cause various retinal degnerative diseases.

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) interaction partners

  1. SEMA4A is required for optimal activation of mTORC1 in CD8 (show CD8A Proteins)+ T cells.

  2. Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 (show NRP1 Proteins) axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity

  3. Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development.

  4. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  5. A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans.

  6. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.

  7. Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries.

  8. Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness.

  9. experiments using knockout mice revealed that Sema4A but not Sema7A (show SEMA7A Proteins) was required for the effect produced by Th1 (show HAND1 Proteins) cells on neurite outgrowth from cortical neurons.

  10. Data indicated that Sema4A could function as a chemo-repulsive cue by activating a receptor whose signal is transmitted to Rho-kinase (show ROCK2 Proteins) and induced growth cone collapse of hippocampal neurons.

Sema4a Protein Profile

Protein Summary

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Sema4a

  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (SEMA4A)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a)
  • AI132332 protein
  • CORD10 protein
  • RP35 protein
  • SEMA4A protein
  • Semab protein
  • SemB protein

Protein level used designations for Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPECIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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