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Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Additionally we are shipping SEMA4D Antibodies (238) and SEMA4D Proteins (29) and many more products for this protein.
Showing 10 out of 18 products:
Human SEMA4D ELISA Kit for Sandwich ELISA - ABIN417637
Anastasilakis, Polyzos, Makras, Gkiomisi, Sakellariou, Savvidis, Papatheodorou, Kokkoris, Terpos: Circulating semaphorin-4D and plexin-B1 levels in postmenopausal women with low bone mass: the 3-month effect of zoledronic acid, denosumab or teriparatide treatment. in Expert opinion on therapeutic targets 2014
Tax (show CNTN2 ELISA Kits) and semaphorin 4D released from lymphocytes infected with human lymphotropic virus type 1 and inhibit neurite growth in a neuron cell line.
This assay specifically and reproducibly measured cSEMA4D saturation and expression levels. Evaluation of the SEMA4D-specific PD markers were critical in determining the clinical saturation threshold of cSEMA4D by VX15/2503
Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.
this study describes a novel immunosuppressive role for Sema4D in head and neck squamous cell carcinoma through induction of myeloid derived suppressor cells
Plexin-B1 (show PLXNB1 ELISA Kits) induces cutaneous squamous cell carcinoma cell proliferation, migration, and invasion by interacting with Sema4D. Plexin-B1 (show PLXNB1 ELISA Kits) might serve as a useful biomarker and/or as a novel therapeutic target for cSCC (show CYP11A1 ELISA Kits).
Results show that decreased expression of Sema4D, plexin-B1 (show PLXNB1 ELISA Kits) and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.
Blocking of CD100, plexin B1 (show PLXNB1 ELISA Kits) and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.
Suggest that HIF-1alpha (show HIF1A ELISA Kits) and Sema4D expression correlates with histological tumor type, TNM (show ODZ1 ELISA Kits) stage, and lymphatic metastasis in colorectal carcinoma.
A positive feedback loop involving sSema4D/IL-6 (show IL6 ELISA Kits) and TNFalpha (show TNF ELISA Kits)/ADAMTS-4 (show ADAMTS4 ELISA Kits) may contribute to the pathogenesis of rheumatoid arthritis.
Sema4D contributes to enhanced invasion and tumor progression through increased motility of cervical cancer and VEGF-C (show VEGFC ELISA Kits)/-D-mediated lymphangiogenesis.
Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice
Sema4D-deficiency affected ischemia-induced microglial activation in morphology, iNOS (show NOS2 ELISA Kits) expression, and proliferation, and this deficiency most likely resulted in moderation of cytotoxicity and locomotor behavioral abnormality after cerebral ischemia
The addition of recombinant Sema4D to Sema4D/ vaginal epithelial cells in culture significantly enhanced apoptosis of the vaginal epithelial cells.
Sema4D may be an essential apoptosis-inducing ligand that acts downstream of estrogen action in vaginal epithelium during pubertal tissue remodeling.
therapeutic effects via bone-targeting systems featuring interference of Sema4d are able to partly counteract alveolar bone loss caused by osteoporosis.
CD100-mediated signals are critical for effective activation of gammadelta IEL to produce growth factors, including KGF (show FGF7 ELISA Kits)-1, that are required for healing of the colon epithelium during colitis.
Deletion of plexin-B1 (show PLXNB1 ELISA Kits), the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.
Data indicate neuroimmune semaphorin 4D (Sema4D) as an important regulator of Th2-driven lung pathophysiology and as a potential target for a combinatory disease immunotherapy.
Sema (show SEMA3B ELISA Kits) 4D/CD100 is not only a ligand for plexin B1 (show PLXNB1 ELISA Kits) but also a direct signaling receptor in mediating Sema (show SEMA3B ELISA Kits) 4D/CD100-plexin B's biological functions.
CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted gamma-delta T cell response to keratinocyte damage.
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system\; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).
, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
, M-sema G
, sema J
, semaphorin H
, semaphorin-C-like 2
, semaphorin 4D