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Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Additionally we are shipping SEMA4D Antibodies (148) and SEMA4D Kits (20) and many more products for this protein.
Showing 10 out of 27 products:
Cynomolgus SEMA4D Protein expressed in Human Cells - ABIN2009989
Duran-Struuck, Tawara, Lowler, Clouthier, Weisiger, Rogers, Luker, Kumanogoh, Liu, Ferrara, Reddy: A novel role for the semaphorin Sema4D in the induction of allo-responses. in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007
Show all 2 references for ABIN2009989
Mouse (Murine) SEMA4D Protein expressed in Human Cells - ABIN2008092
Chng, Kumanogoh: Roles of Sema4D and Plexin-B1 in tumor progression. in Molecular cancer 2010
Show all 2 references for ABIN2008092
Human SEMA4D Protein expressed in HEK-293 Cells - ABIN2181739
Delaire, Billard, Tordjman, Chédotal, Elhabazi, Bensussan, Boumsell: Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration. in Journal of immunology (Baltimore, Md. : 1950) 2001
Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.
this study describes a novel immunosuppressive role for Sema4D in head and neck squamous cell carcinoma through induction of myeloid derived suppressor cells
Plexin-B1 (show PLXNB1 Proteins) induces cutaneous squamous cell carcinoma cell proliferation, migration, and invasion by interacting with Sema4D. Plexin-B1 (show PLXNB1 Proteins) might serve as a useful biomarker and/or as a novel therapeutic target for cSCC (show CYP11A1 Proteins).
Results show that decreased expression of Sema4D, plexin-B1 (show PLXNB1 Proteins) and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.
Blocking of CD100, plexin B1 (show PLXNB1 Proteins) and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.
Suggest that HIF-1alpha (show HIF1A Proteins) and Sema4D expression correlates with histological tumor type, TNM (show ODZ1 Proteins) stage, and lymphatic metastasis in colorectal carcinoma.
A positive feedback loop involving sSema4D/IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins)/ADAMTS-4 (show ADAMTS4 Proteins) may contribute to the pathogenesis of rheumatoid arthritis.
Sema4D contributes to enhanced invasion and tumor progression through increased motility of cervical cancer and VEGF-C (show VEGFC Proteins)/-D-mediated lymphangiogenesis.
SEMA4D might possibly serve as a reliable tool for early and accurate prediction of EOC poor prognosis.
results suggest that the contribution of Sema4D in platelets applies to ITAM-containing receptors as a class
Sema4D-deficiency affected ischemia-induced microglial activation in morphology, iNOS (show NOS2 Proteins) expression, and proliferation, and this deficiency most likely resulted in moderation of cytotoxicity and locomotor behavioral abnormality after cerebral ischemia
The addition of recombinant Sema4D to Sema4D/ vaginal epithelial cells in culture significantly enhanced apoptosis of the vaginal epithelial cells.
Sema4D may be an essential apoptosis-inducing ligand that acts downstream of estrogen action in vaginal epithelium during pubertal tissue remodeling.
therapeutic effects via bone-targeting systems featuring interference of Sema4d are able to partly counteract alveolar bone loss caused by osteoporosis.
CD100-mediated signals are critical for effective activation of gammadelta IEL to produce growth factors, including KGF (show FGF7 Proteins)-1, that are required for healing of the colon epithelium during colitis.
Deletion of plexin-B1 (show PLXNB1 Proteins), the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.
Data indicate neuroimmune semaphorin 4D (Sema4D) as an important regulator of Th2-driven lung pathophysiology and as a potential target for a combinatory disease immunotherapy.
Sema (show SEMA3B Proteins) 4D/CD100 is not only a ligand for plexin B1 (show PLXNB1 Proteins) but also a direct signaling receptor in mediating Sema (show SEMA3B Proteins) 4D/CD100-plexin B's biological functions.
CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted gamma-delta T cell response to keratinocyte damage.
Sema4D may act as an intrinsic inhibitory regulator of oligodendrocyte differentiation by promoting apoptosis.
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system\; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).
, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
, M-sema G
, sema J
, semaphorin H
, semaphorin-C-like 2
, semaphorin 4D