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Binds to plexin family members and plays an important role in the regulation of developmental processes. Additionally we are shipping SEMA3C Antibodies (71) and SEMA3C Kits (13) and many more products for this protein.
Showing 9 out of 9 products:
The exploratory genome-wide association studies confirmed APOE (show APOE Proteins) and identified the novel loci: rs2525776 near SEMA3C (P = 1 x 10(-8), OR = 3.3 [2.1-5.1]).
Aberrant expression of sema3c is correlated with poor prognosis of pancreatic ductal adenocarcinoma patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway.
FR-sema3C could perhaps be used for the treatment of AMD (show AMD1 Proteins).
SEMA3C plays a role in the progression of breast cancer and may positively influence breast cancer cell adhesion, invasion and proliferation, as well as being associated with grade of disease and estrogen receptor (show ESR1 Proteins) status.
Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 (show NRP2 Proteins) in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels.
Increased levels of Sema3C protein may be associated with the progression of glioma tumor and have potential as a prognostic marker for outcome of glioma patients.
SEMA3C expression increased in the transition from normal to malignant breast lesions and correlated with microvessel density and tumour grade and is differentially regulated in the development of breast versus oral neoplasia.
Glioma stem cells preferentially secrete Sema3C and coordinately express PlexinA2/D1 receptors to activate Rac1/nuclear factor (NF)-kB signaling.
p65 (show GORASP1 Proteins)-Sema3C, but not FR-sema3C, rendered A549 lung cancer cells resistant to serum deprivation, suggesting that previously reported protumorigenic activities of sema3C may be due to p65 (show GORASP1 Proteins)-Sema3C produced by tumor cells
Functional loss of semaphorin 3C and/or semaphorin 3D (show SEMA3D Proteins) and their epistatic interaction with ret (show RET Proteins) are critical to Hirschsprung disease liability.
analyzed a complementary set of ligand-specific and tissue-specific mutants to show that neural crest-derived SEMA3C activates NRP1 (show NRP1 Proteins) in the cardiac outflow tract endothelium
Sema3A (show SEMA3A Proteins) overrides the effects of Sema3C in cortical axons exposed to defined mixtures of these opposing guidance cues in vitro
No changes were observed in the binding of Sema3C to Nrp1 (show NRP1 Proteins)-silenced B16(F10 (show F10 Proteins)) cells, nor in its chemorepellent activity.
Data suggest that the formation and synaptic specificity of the GABAergic septohippocampal pathway relies on robust molecular mechanisms, independent of semaphorin 3C.
the guidance factor Semaphorin 3C, which is expressed by corpus callosum neurons, acts through the neuropilin 1 (show NRP1 Proteins) receptor to orient axons crossing through the corpus callosum.
Secreted sema3C favors cell survival and neuritogenesis of cultured cerebellar granule neurons
GATA-6 (show GATA6 Proteins) regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis
sema (show SEMA3B Proteins) 3C promotes glomerular endothelial cell proliferation, adhesion, directional migration, and tube formation in vitro by stimulating integrin phosphorylation and VEGF120 (show VEGFA Proteins) secretion
Npn1 (show NRP1 Proteins)-dependent morphogenesis is mediated by Sema3A (show SEMA3A Proteins) and Sema3C in an additive manner.
The endocytic pathway of neuropilin(Nrp)1 (show NRP1 Proteins) depends on its ligand: sema3C induces lipid raft-dependent endocytosis.
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).
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